Products in Excipients: Tablet Coating

BIOGRUND’s ready-to-use printing ink BonuPrint® is a fine, homogenous, liquid pigment dispersion for solid oral dosage forms, available as an organic or aqueous solution.

METOLOSE® SM 4 consists of methyl cellulose (USP, JP, EP) and three substitution types of hydroxypropyl methyl cellulose (hypromellose USP, JP, EP) each available in several grades differing in viscosity.

TYLOPUR® 605 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs.It also enhances the solubility of poorly solule APIs.

PHARMACOAT® 603 is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. It is easy to use it as a film coating material that provides an excellent finish

METOLOSE® SR 90SH-4000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-15000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-100000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-100SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

TYLOPUR® is a versatile hypromellose, compliant with USP, JP, EP. TYLOPUR® 60SH-50 provides a genuine consistency in Sustained release (matrix tablets). It also can be used as thickener in aqeous solution .It is also a good suspending agent in colloidal solution.

PHARMACOAT® 606 is a binder, it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, PHARMACOAT®® replaces gelatin in hard capsule manufacturing. It is also used as taste making agent for bitter tasting drugs.

TYLOPUR® 645 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs.It also enhances the solubility of poorly solule APIs.

TYLOPUR® 606 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs.It also enhances the solubility of poorly solule APIs.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-21 is suitable for wet granulation.

HPMCP is a monophthalic acid ester of hypromellose.HP-55S is enteric coating agent with greater strength and higher acid resistance due to its high molecular weight

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-22 is suitable for direct compression.

HPMCP is a monophthalic acid ester of hypromellose.HP-50 is enteric coating agent soluble at lower pH

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-32 is suitable for wet granulation, pellet extrusion and layering.

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application. L-HPC LH-31 is suitable for wet granulation, pellet extrusion and layering.

HPMCP is a monophthalic acid ester of hypromellose.HP-55 is a regular grade enteric coating agent.

AquaPolish® C has been developed to improve running production processes. Furthermore, it is an ideal basis for researching new solutions. The contract manufactured compound is a unique, dry milled, homogeneous blend of film coating polymers, plasticizing and coloring additives and other excipients. It can be applied by using conventional or modern coating equipment.

CompactCel® DIS is a natural/organic super-disintegrant which enables a rapid break-up of solid dosage forms when they come into contact with moisture. The super-disintegrant premix is formulated with natrual ingredients which complies with current Clean Label Standards. It provides an alternative to synthetic super-disintegrants, such as crosslinked polymers, crosscarmellose sodium or sodium starch glycolate. CompactCel® DIS helps in the fast breakdown of the solid dosage form so that the active ingredient becomes bioavailable faster and is readily absorbed. It can be also used in the formulation of oral disintegrating tablets (ODT) or chewing tablets.

The ingredient premix CompactCel® MAB provides an oil and moisture holding capacity and prevents clumping of your powder blend. The homogeneous dry powder product controls humidity related issues in formulas or absorbs oily substances into free flowing powder.

CompactCel® FLO is a flow agent for loosening powder mixtures and improving flowability. The ready-touse powder compound replaces synthetic additives such as silicon dioxide. It prevents bridge formation during flow from hopper and provides a clean funnel flow of the powder mass to be processed during both tableting and capsule filling.

BIOGRUND’s ready-to-use coloring agent TopMill® G provides a homogeneous solid-colored product. It is a unique, dry milled, homogeneous blend of Candurin® pearl effect colors with additional excipients. The widely approved mineral colors are based on natural silicate combined with titanium dioxide and/or iron oxide and give your tablets a brilliant and unique appearance.

BIOGRUND’s tableting agent CompactCel® TC provides an easy to use and homogeneous compound of several sugar alcohols and cellulose fibers, which acts as a perfect taste masking dry binder.

IsuPolish® FSC is a unique, dry milled, homogeneous blend of hypromellose, Isomalt or sucrose, pigments and additional excipients. Compared to a traditional sugar-coating process this product assists you to speed up the production process.

BIOGRUND’s one-step film coating system AquaPolish® OM perfectly masks bad and strong smelling actives (e. g. herbal extracts). Sealing these characteristics by using AquaPolish® OM enables a pleasant application for the consumer and increases patient compliance. It provides a protective and economical coating on tablets, pellets, granules and capsules without influencing the disintegration time.

BIOGRUND’s one-step tabletting agent CompactCel® SIL provides an easy to use, granulated and homogeneous compound of Silica and PVP/ NaCMC or HPC/NaCMC, which acts as a perfect dry binder granulate.

BIOGRUND’s sugar-coating system IsuPolish® provides a sugar-free dragée which has a pure and natural taste. It is suitable for diabetics (because of its low glycemic and low insulinemic response) and its cario-static properties.

AquaPolish® TC is a combination of HPMC, HPC and other cellulose ethers with taste masking additives. Due to the further additives, which form a hardly soluble film, a tastemasking is achieved.

AquaPolish G has been developed for the coating of all kinds of solid dosage forms. It is easily soluble and a reproducible high-quality film coating can be guaranteed. The widely approved, mineral colors of Candurin® are based on natural silicate combined with titanium dioxide and/or iron oxide.

AquaPolish® STA has been developed for the fast coating of oral solid dosage forms. It is easily soluble and a reproducible high-quality film coating can be guaranteed. Due to its high solid content of 20–25% in the dispersion, a fast application at low process temperatures will improve your production process and save time. Additionally, your product gains a small barrier against moisture.