Browse Products by Market

Browse Products by Technology

Our mission, together with our selected business partners, is to offer a complete range of high-quality cellulose ether derivative products and best in class technical support to the pharmaceutical, nutraceutical and food additives markets.We offer the services of our fully equipped technical application laboratories in Totowa, NJ and Wiesbaden, Germany to support your development efforts and help solve your technical challenges.Our global approach to manufacturing, R&amp;D, technical support and sales activity allows Shin-Etsu to provide high-quality, value-added products that align with the goals of our customers.&nbsp;&nbsp;

Tylopur MCE-100TS is the strongest gelling methylcellulose offered in our portfolio.  The unique thermal gelation property gives the #bestbite to your plant-based meats.

TYLOPUR® MCE-100TS

Tylopur NE-15000 is a soft-gelling HPMC with high sugar tolerance that creates softness and structure to gluten-free breads and stabilization to savory and sweet fillings.

TYLOPUR® NE-15000

Tylopur Xtend Nutra® (4,000 mPa·s) is the natural ingredient of choice for formulating robust, sustained release supplements.  

TYLOPUR XTEND NUTRA® 4T

Tylopur Xtend Nutra® (15,000 mPa·s) is the natural ingredient of choice for formulating robust, sustained release supplements.  

TYLOPUR XTEND NUTRA® 15T

Tylopur ClearCoat Nutra® 5T is a natural ingredient for film coating.  Also for use in wet granulation to improve particle size, powder flow and compressibility of actives.

TYLOPUR CLEARCOAT NUTRA® 5

Tylopur ClearCoat Nutra® 15T is a natural ingredient for film coating.  Also for use in wet granulation to improve particle size, powder flow and compressibility of actives.

TYLOPUR CLEARCOAT NUTRA® 15

Privacy

Terms & Conditions

Terms of Sale

Cookie Policy

Shin-Etsu Chemical Co., Ltd. began to produce water soluble cellulose ethers in 1962, with the trade name METOLOSE®. METOLOSE® consists of Methylcellulose (methylcellulose USP) and three substitution types of Hydroxypropylmethylcellulose (Hypromellose USP) each available in several grades differing in viscosity. METOLOSE® can be used as a binder for solid dosage forms such as tablets and granules. It also provides a variety of functions such as water retention, thickening, protective colloid, surface activity, etc. It also can be used as a hydrophilic matrix agent. The hydrophilic matrix system is the simplest sustained release technology for oral dosage forms, consisting essentially of a drug and a water soluble highly viscous polymer. Recent advances in this hydrophilic matrix system have allowed more controllable and reproducible drug release by controlling the chemical and physical properties of the polymer. METOLOSE® SR is especially suitable for this application, and provides a genuine consistency in the final products.


METOLOSE

TYLOPUR® is a versatile hypromellose, compliant with USP, JP, EP. The low viscosity grades are especially suitable for the design of film-coated tablet formulations.
In addition, TYLOPUR® is effective as a binder, since it does not interact with drugs. It has superior stability, a non-ionic character and is widely used as a binder for granulation. Due to its plant derived nature and excellent moisture stability, TYLOPUR® replaces gelatin in hard capsule manufacturing.

TYLOPUR

Shin-Etsu Chemical's PHARMACOAT® was developed from hydroxypropyl methylcellulose in 1963, during the early days of film coating, and has been the subject of a continuous program of development and quality improvement since then. Film coatings of this type are now in widespread use throughout the world. Although drug properties are the key factor in medicinal formulations, the physical form or the finish of a preparation is also important. PHARMACOAT® is easy to use as a film coating material and gives an excellent finish. It is very versatile, and is suitable for many applications in the design of film-coated tablet formulations. In addition, PHARMACOAT® is effective as a binder, since it does not interact with drugs, and has superior stability, nonionic character, etc. PHARMACOAT® is widely used as a
binder for granulation, and is available in various viscosity grades for granulation purposes. Shin-Etsu Chemical's PHARMACOAT® can make a valuable contribution in various areas of pharmaceutical technology.


PHARMACOAT

An enteric coating agent is used to protect drugs from degradation by gastric acid or to protect gastric mucosa from irritating drugs. HPMCP (Hypromellose Phthalate), since its introduction into the market in 1971 as an alternative cellulose derivative for enteric coating, has been demonstrated to be an effective and safe material by many researchers and is widely used as an enteric coating agent by the pharmaceutical industry. HPMCP has been admitted into the U.S. National Formulary (USP/NF), European Pharmacopeia (EP), and Japanese Pharmacopeia (JP).
The chemical structure of HPMCP is a monophthalic acid ester of Hypromellose (hydroxypropyl methylcellulose), and the threshold pH value for rapid disintegration of HPMCP can be controlled by varying the phthalyl content. Two types of HPMCP with different in pH-solubilities, HP-55 and HP-50, are available. Moreover, HP-55S, a special type of HP-55, which is distinguished by its higher molecular weight, greater film strength and higher acid resistance properties, has also been introduced. A suitable grade of HPMCP for a particular purpose should be selected in accordance with each preparation.

HPMCP

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC.   L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.

L-HPC

Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.                                                               Hypromellose is a non-toxic material which has been used in pharmaceutical, food, and cosmetic industries for many years. Based on hypromellose, acetyl and succinoyl groups are introduced to the hydroxyl groups of the backbone, and this constitutes Shin-Etsu AQOAT®, hypromellose acetate succinate (HPMCAS).
There are nine grades with different particle sizes (fine, medium, granular) and chemical substitution levels of acetyl and succinoyl groups to obtain an opening pH range from 5.5 to 6.5.
Shin-Etsu AQOAT® is the leading polymer in solid dispersion technology. It is suitable for spray-drying, hot melt extrusion, co-precipitation and other techniques. There are more than 14 approved products in the US using Shin-Etsu AQOAT® in solid dispersion.
Additionally, we designed our HME cleaner to support you with trouble free cleaning after the extrusion process. Please contact us for further information.

Shin-Etsu AQOAT

TYLOPUR Xtend Nutra® is a plant derived ingredient (high viscous hydroxypropyl methylcellulose, HPMC) that has been developed by Shin-Etsu to provide a controlled, extended release of active compounds over a longer period of time, prolonging their effects on human body. TYLOPUR Xtend Nutra® acts as a hydrophilic matrix agent in hydrophilic matrix system, which is the simplest sustained release technology, consisting essentially of an active compound and a water soluble highly viscous natural polymer. Such a system allows a simple and straight forward direct compression formulation and a reduction of doses per day. It is not only cost effective but it is also consumer friendly. The mechanism of action of TYLOPUR Xtend Nutra® in hydrophilic matrix tablets consists of initial swelling caused by the hydration of a tablet, protective gel formation, which regulates the degree of active compound’s release, and time-related extended release of an active compound through the gel layer.


TYLOPUR XTEND NUTRA

TYLOPUR ClearCoat Nutra® is a plant derived, water soluble ingredient (low viscous hydroxypropyl methylcellulose, HPMC) that has been developed by Shin-Etsu as a natural and easy-to-use material for film coating of nutraceutical and nutritional supplement tablets. It can be quickly dissolved in water at room temperature and does not require any additional ingredients for a successful coating. TYLOPUR ClearCoat Nutra® provides an excellent finish, that can protect tablets from humidity and reduces their overall friability during packaging. Moreover, coating with TYLOPUR ClearCoat Nutra® can improve the mouth feel and swallowability for consumers.

Additionally, TYLOPUR ClearCoat Nutra® is recommended for wet granulation to improve particle size, powder flow and compressibility of nutraceutical actives.


TYLOPUR CLEARCOAT NUTRA

SmartEx® is a co-processed excipient including L-HPC (disintegrant), polyvinyl alcohol (PVA, binder) and mannitol (filler). With good compressibility and rapid disintegration, as well as its free powder flow, SmartEx® is excellent for oral dispersible tablets (ODTs) by direct compression processes. A DMF is available.

SmartEx

TYLOPUR® 605 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs.It also enhances the solubility of poorly solule APIs.

TYLOPUR® 605

Shin-Etsu AQOAT® AS-MF -Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

Shin-Etsu AQOAT® AS-MF

SmartEx® is a co-processed excipient which consists of L-HPC, D-mannitol and fully hydrolyzed polyvinyl alcohol (PVA) and it specially designed for orally disintegration tablets (ODTs) and also immediate release tablet formulation by direct compression. All the excipients are widely used in pharmaceutical industry. One of the main advantage over other co-processed excipients is that SmartEx® contains L-HPC and therefore gives excellent stability.

SmartEx® QD-50

TYLOPUR® 606 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs.It also enhances the solubility of poorly solule APIs.

TYLOPUR® 606

Amorphous solid dispersion is a technology for solubility enhancement of drugs.Shin-Etsu AQOAT® AS-MMP is used as solubility enhancement of poorly soluble APIs.

Shin-Etsu AQOAT® AS-MMP

METOLOSE® SR 90SH-4000SR provides a genuine consistency in Sustained release (matrix tablets). It can be used for semi solid drug products.

METOLOSE® SR 90SH-4000SR

TYLOPUR® 615 is a versatile hypromellose, compliant with USP, JP, EP. It is a film coating material that provides an excellent finish.It is a effective binder, it does not interact with drugs. It is an excellent taste making agent for bitter tasting drugs.

TYLOPUR® 615

Shin-Etsu AQOAT® AS-LG -Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

Shin-Etsu AQOAT® AS-LG

Shin-Etsu AQOAT® AS-LF -Hypromellose acetate succinate (HPMCAS, NF, JP) is an enteric coating material that can be used in aqueous or organic media.It is also used as solubility enhancement of poorly soluble APIs.

Shin-Etsu AQOAT® AS-LF

Shin-Etsu Pharma, Nutra and Food

Our mission, together with our selected business partners, is to offer a complete range of high-quality cellulose ether derivative products and best in class technical support to the pharmaceutical, n

Shin-Etsu Pharma, Nutra and Food - Knowde

Website

LinkedIn

Identification & Functionality

Features & Benefits

Applications & Uses

Properties

Regulatory & Compliance

Technical Details & Test Data

Safety & Health

Packaging & Availability

Storage & Handling

Innovation Hub

TYLOPUR® 90SH-100000SR

Knowde is the first marketplace for chemicals, polymers and ingredients. Our leading-edge digital capabilities connect thousands of sellers and buyers every day.

TYLOPUR - 90SH-100000SR - Shin-Etsu - 9004-65-3 - Non-GMO

Chemical Name

Functions

Labeling Claims

Job Title

Shipping Terms

Name

and the data associated with it — permanently.

This is a Premium Feature

Changes to filters have not been applied.

Discard changes?

{userCompanyName} notice

{userCompanyName} requires all users on {companyName} to register with their business email address to ensure confidentiality and security.

In order to join {userCompanyName} on Knowde, you must use your business email address.

Business already on Knowde

There's only a little ways to go.

Creating an account is free and the only way to directly download documents, order samples, request quotes and use direct messaging.

Quit Sign Up?

Enter the 6-digit code sent to {email}

Verification email sent

Since you're using a personal email address, we require additional information about your business.

Tell us about your business

from concierge@knowde.com

Click the link in the email, or enter the 6-digit code

Our team will reach out to you shortly to schedule a demo.

Good news, your demo request has been submitted!

Since you’re using a personal email address, we require proof to verify the information you have provided.

Please verify your account

Also, using a personal email for creating your {companyName} account may require additional verification of your company details.

Please go back and enter in an email address that is directly associated with a business.

Knowde is built for businesses

Please enter your business email address below.  We’ll send you a confirmation code to quickly verify.

Enter your business email

Knowde is for businesses, you may have a hard time receiving responses to your requests if you use a personal email address.

to {email}

We sent an email to {email}

Please click the link to reset your password

Check your email

Create a new password

For security purposes, please create a new password

Password expired

Sign in to {companyName}

Get a Demo

Don’t have an account? Ask your admin for access or 

Enter a new secure password

Enter a new password for your account

Change your password

Enter the email address associated with your account

Enter the email associated with your account and we’ll send you instructions to reset your password.

Reset your password

Forgot password?

If the email address you've entered is registered to a knowde account, you should receive instructions to reset your password soon. Remember to check your spam or junk folder as well.

If the email you’ve entered is registered to a Knowde account, you should receive an email with instructions for resetting your password shortly.

If you don’t receive it, try checking your spam or junk folder.

Password successfully reset!

Your data is protected and secured. Your information is only shared with Knowde Suppliers you’ve expressed interest in.

Enter your password for

Use your Knowde password to sign in:

Please provide additional information to help us verify your company.

Tell us about {userCompanyName}

Terms and Conditions

Compare multiple products at once and find the best fit for your project needs.

Why is this important?

Enter new password

Recover your account

Learn how to take full advantage of the free to use tools that you have unlocked.

Explore the capabilities of the platform and get immediate assistance for your needs with one of our experts.

Schedule a Demo

You’ll meet with Kiana from our Knowde Marketplace Team

Explore the capabilities of the platform and get immediate assistance for your needs.

Learn how you can make the most of the free tools now available to you.

Explore the capabilities of the platform with our dedicated team.

Weekly Webinar

View All Products

Cart

Please fix the following before proceeding to payment

An order receipt has been emailed to {email}

Order

This feature is currently unavailable at this screen size.

Payment

Shipping

Checkout

Compare Products

Quick and easy product classifications and attributes comparison side by side.

{price} each for {name}

This document is restricted content.

If you believe you should have permission to this document, please request access.

Restricted Access

Sign in or create a free account to view

{supplier} requires you to create an account to view their documents.

Available {documentType} documents for this product ({counter})

Describe Documents You’d Like to Request

Since you're using a personal email address, we require proof to verify the information you have provided.

Invalid job title

That’s not the reaction we were expecting.

Page not found - Store for chemicals, polymers and ingredients

Internal Server Error - Store for chemicals, polymers and ingredients

Unexpected error occurred. Please contact us.

Client Side Exception - Store for chemicals, polymers and ingredients

{companyName} experts - Knowde

Show products with

Filters

Featured Products

Flavor & Taste Explorer

Flavor Families

Enter your inquiry here, include as much detail as you’re able. *

To submit an inquiry to {companyName}, please fill out the form below and click Submit. They will get back to you as soon as they’re able.

Knowde is the first marketplace for chemicals, polymers and ingredients. Our leading-edge digital capabilities connect thousands of suppliers and customers every day.

Chemicals Marketplace - ingredients & raw materials - Knowde

Request samples, documents, and quotes directly from suppliers

Insufficient Permissions:

You cannot submit this request due to:

Knowde is the world’s biggest marketplace to search for ingredients, polymers, and chemistry.  You can:

See which others might better fit your needs.

This is just one of {allProducts} products on Knowde.

BROWSE THE MARKETPLACE BY

Knowde Software Solutions

Most popular categories

Gain instant access to our marketplace of over 250,000 chemicals, ingredients and polymers from 8,000 suppliers. Browse, search, and filter to quickly compare products, find information, request documents, order samples, and get quotes directly from suppliers.

Search and filter over 250,000 chemicals, ingredients and polymers, access documents and download starter formulations. Interact with over 8,000 suppliers whose representatives are ready to help. Sign up for a free Knowde Marketplace account today.

Create a free account to gain instant access to our marketplace of over 250,000 products and their documents.

Food & Nutrition Formulations

Agriculture & Feed

Sustainable Cosmetic Ingredients

Agrochemicals

TYLOPUR® 90SH-100000SR

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Features & Benefits

Applications & Uses

Properties

Regulatory & Compliance