Enhanced TDS
Knowde-enriched technical product data sheet
Identification & Functionality
- Chemical Name
- Pharma & Nutraceuticals Functions
- CAS No.
- 9050-31-1
- EC No.
- 618-567-3
- Technologies
- Product Families
- Structure
Features & Benefits
- Labeling Claims
- Features
- Suitable for solvent coating system. As co-solvents, mixture of ethanol and water (80/20 w/w%) or mixture of acetone and water (95/5 w/w%) are recommendable.
- Relatively stable, due to less hydrolysis.
- Available as a solid dispersion carrier for solubility enhancement.
Applications & Uses
- Markets
- Applications
- Dosage Form
- Manufacturing Technology
- Application
- HPMCP is Very Suitable for Taste Masking
- HPMCP is Very Suitable for Enteric/delayed release coating (solvent)
- HPMCP is Suitable for Solvent free methods
- HPMCP is Very Suitable for Solvent methods
- Tablet Coating
- Granule Coating
Properties
- Physical Form
- Typical Properties
Value Units Test Method / Conditions Chloride Not more than 0.07 % USP/NF Dissolving pH min. 5.5 - - Free phthalic Acid Not more than 1.0 % USP/NF Heavy Metals Not more than 0.001 % USP/NF Hydroxy propoxy Content 5.0 - 9.0 % USP/NF Labeled Viscosity 40.0 cSt - Methoxy Content 18.0 - 22.0 % USP/NF Nominal Phthalyl Content 31.0 % - phthalyl Content 27.0 - 35.0 % USP/NF Residue on ignition Not more than 0.20 % USP/NF Viscosity 32 - 48 cSt USP/NF Viscosity 40.0 mPa.S - Water Not more than 5.0 % USP/NF - Note
*Viscosity of 10 w/w% solution of methanol and dichloromethane at 20°C
- Solubility in Various Organic Solvents
HPMCP Shin-Etsu
AQOATHP-55
HP-55SHP-50 AS-MG Acetone ○ △ ○ Acetone/water (95:5)* ○ ○ ○ Acetone/ethanol (1:1)* ○ ○ ○ Dichloromethane △ △ △ Dichloromethane/ethanol (1:1)* ○ ○ ○ Dioxane ○ ○ ○ Methanol △ △ ○ Isopropanol △ × × Ethanol × × × Ethanol/water (8:2)* ○ ○ ○ Ether × × × ○ : soluble, △ : swollen or partially soluble × : insoluble, * : mixing ratio by weight
Regulatory & Compliance
- Certifications & Compliance
- Chemical Inventories
- Grade
Technical Details & Test Data
- Solubility
According to the disintegration test method, dissolution time was measured for cast film from organic solvent (thickness: 100 μ m; size: 10 x 10 mm)
〜 pH 5.6: USP Phthalate buffer
pH 5.8 〜: USP Phosphate buffer
Packaging & Availability
Storage & Handling
- Storage
Keep dry. Store away from excess heat and sunlight. Store in sealed containers.