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Pleiotanicals® Grandiciin® (R10124)

Grandiciin® (R10124) is an Epimedium extract featuring a beneficial mix of prenylated flavonoids for addressing blemished skin. Applications for Grandiciin® include microbiome-balancing products, anti-blemish and spot treatments, anti-sebum and oil-reducing hair and skin care, and soothing and calming body care regimens for damaged skin. Grandiciin® improves skin health and wellness through microbiome-rebalancing activity, reducing the problematic Cutibacterium acnes (formerly Propionibacterium acnes) biofilms that contribute to inflammation, redness, and blemish formation. Grandiciin® is clinically shown to diminish C. acnes burden on the skin while also reducing sebum (oil) production and signs of inflammation and redness and improving the appearance of blemishes in four weeks. Grandiciin® addresses inflammatory, proteolytic, and oxidative stress to provide an extra layer of protection against tissue damage and scarring in severely blemished skin.

Brand: Pleiotanicals (9 products)

INCI Name: Epimedium Sagittatum Leaf/Stem Extract

Ingredient Origin: Natural Origin, Plant Origin

Functions: Anti-Inflammatory

Labeling Claims: Gluten-free, Natural, Naturally Derived, Non-Irritant, Not Tested on Animals, Plant-Based, Preservative-free, Sustainable, Vegan

Benefit Claims: Age & Dark Spot Reduction, Antioxidant Properties, Bacterial Biofilm Reduction, Blemish Control, Calming, Compatibility, Improves Skin Appearance, Protection From Environmental Damage, Redness Reduction, Sebum Control, Skin Microbiome, Skin Microbiome Friendly, Skin Protection, Soothing, Spot Prevention, Stress Reducing, Suitable for Oily Skin

Certifications & Compliance: California Proposition 65

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Carrier
Propanediol
INCI Name
Epimedium Sagittatum Leaf/Stem Extract
Ingredient Origin
Natural Origin,
Plant Origin
Cosmetic Ingredients Functions
Anti-Inflammatory
Technologies
Cosmetic Ingredients
Product Families
Cosmetic Ingredients — Cosmetic Actives
Skin Actives
Origin
Grandiciin® is a plant-dervied active produced from Epimedium sagittatum, rich in a beneficial mix of prenylated flavonoids including icariin and epimedins

Features & Benefits

Benefit Claims
Age & Dark Spot Reduction,
Antioxidant Properties,
Bacterial Biofilm Reduction,
Blemish Control,
Calming,
Compatibility,
Improves Skin Appearance,
Protection From Environmental Damage,
Redness Reduction,
Sebum Control,
Skin Microbiome,
Skin Microbiome Friendly,
Skin Protection,
Soothing,
Spot Prevention,
Stress Reducing,
Suitable for Oily Skin
Labeling Claims
Gluten-free,
Natural,
Naturally Derived,
Non-Irritant,
Not Tested on Animals,
Plant-Based,
Preservative-free,
Sustainable,
Vegan
Benefits & Claims
  • Plant-derived active produced from Epimedium sagittatum
  • Contains beneficial flavonoids and flavonoid derivatives including icariin and epimedins
  • Helps to reduce biofilm-resident C. acnes, which is particularly abundant in blemished skin
  • Inhibits production of inflammatory mediators: MIP-1β, MCP-1, IL-1β, IL-6, IL-8, GM-CSF
  • Modulates pro-inflammatory PLA2 and COX-2 activities
  • Protects the extracellular matrix via inhibition of proteolytic stress
  • Protects against oxidative damage due to inflammation and environmental stress
  • Modulates the expression of 11 genes to improve skin’s appearance Clinical trial results showed:
  • 25% reduction in sebum in just two weeks
  • 36% reduction of C. acnes-associated coproporphyrin III
  • Significant improvement of blemishes and redness

Applications & Uses

Markets
Personal Care
Applications
Personal Care — Beauty & Care
Skin Care,
Treatment Products
Application Format
Leave On,
Masks,
Rinse Off
Skin Care Applications
Anti-Spot Products,
Facial Mask
Treatment Product Applications
Scar Treatment
Use Level
0.5 - 2.5%
Applications
  • Skin health and wellness to maintain skin homeostasis through microbiome-rebalancing
  • Formulas to address mild-to-moderate blemishes in young and adult consumers
  • Clay masks and other skin care products targeting consumers with oily skin
  • Soothing and calming products for damaged skin
  • Body care products
  • Spot treatments
Compatibility and Formulation
Grandiciin® is compatible with most conventional ingredients used in skincare products. It is miscible in aqueous and glycolic systems. Add in the last step of formulation when temperature is below 50°C. Mix well before use.

Properties

Physical Form
Liquid

Regulatory & Compliance

Certifications & Compliance
California Proposition 65
Regulatory Information
  • This product has not been tested on animals, and our company adheres to the written provisions of such animal rights organizations as Leaping Bunny and Cruelty/Free International.
  • This product contains no animal products. It is manufactured using only plant based or synthetically derived (non-animal origin) materials and is thereby declared a Vegan Product.
  • All materials used to produce this product are procured using sustainable sourcing practices.
  • This product is manufactured in accordance with the current Good Manufacturing Practices (cGMP) requirements established by the U.S. Food and Drug Administration (FDA) for cosmetics. Furthermore, Biocogent, LLC, and this production facility(ies), are registered as cosmetic manufactures with the FDA.
  • REACH compliance: All of the ingredients (substances) used in the manufacture of this product (mixture)are either registered under REACH, or qualify for an Article 2 (low volume of less than 1 metric ton), Annex IV or Annex V exemption, making our product REACH compliant.
  • Proposition 65 compliance: Based upon Biocogent LLC’s knowledge of our business operations and chemical formulations, no chemicals listed by the State of California Environmental Protection Agency are used in our products, or as a processing aid for any product manufactured in our facility.

Technical Details & Test Data

Test Data

Reduction of C. Acnes Burden & Associated Blemishes

Grandiciin reduces burden on the skin (red fluorescence) while C. acnes also remarkably diminishing the appearance of blemishes, redness, and other signs of inflammation after four weeks of twice-daily application.

Grandiciin® Reduction of C. Acnes Biofilm

 

Over 1200x reduction of problematic biofilm-resident C. acnes with the application of 1.25% Grandiciin®.

Safety & Health

Safety
Human Repeat Insult Patch Testing (HRIPT) under semi-occlusive conditions indicated that Grandiciin®, when tested neat, is not a primary skin irritant or a primary skin sensitizer. EpiOcular(TM) irritancy testing predicted that Grandiciin® would be a Minimal ocular irritant when tested neat and at recommended use levels.

Storage & Handling

Shelf Life
18 Months
Storage Condition
Grandiciin® should be stored at room temperature in original packaging. Protect from extended cold storage and freezing.