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<p><span style="color: rgb(80, 80, 80);">Biocogent, LLC utilizes pioneering technology in research, development, and manufacturing to provide innovative, value-driven functional ingredients and services to its customers in the personal care and cosmetic industries. Rooted in biotechnology, Biocogent utilizes more than 100 years of cumulative expertise in skin, cell and tissue culture and biochemistry. The company deploys the science behind its platform technologies to treat the critical points of beauty including anti-aging, skin renewal, moisturization, skin protection, and detoxification -- all essential for the restoration, revitalization, and maintenance of healthy and youthful skin.</span></p>

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A marine-derived ferment of Sargassum vulgare. Rich in bioactive phlorotannins that rejuvenate and protect through the stimulation of the skin's natural DNA repair processes.

DermalRx® FSE (R10111)

Grandiciin® is a plant-dervied active produced from Epimedium sagittatum, rich in a beneficial mix of prenylated flavonoids including icariin and epimedins.

Pleiotanicals® Grandiciin® (R10124)

Volpura® EP is an Echinacea purpurea extract to address the signs of aging by supporting the skin’s natural plumping processes.

Pleiotanicals® Volpura® EP (R10098)

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HEDI® products has resulted in unique ingredients that provide benefits and value previously impossible to achieve. Stable and infinitely cold-dilutable aqueous products containing very high levels of hydrophobic (oils, butters, non-polar molecules, silicones, etc.) are possible. And, because water remains free and unbound, these products are pumpable, often sprayable, spreadable and easy to handle.
The homogeneity of specific particle size and distribution achieved through HEDI® technology provides a level of formula aesthetics, performance, and functionality not possible by simply adding individual components in situ. HEDI® products are easy to handle, require only simple mixing without heat, and provides significant savings in time during product development and in manufacturing. HEDI® products are excellent choices for a wide range of applications: moisturizing lotions and creams, skin toners, serums, sunscreens, barrier repair products (after shave, post-laser, after-sun), sensitive skin formulas, baby care products, wet wipes, hair conditioners, and many others.

HEDI

DermalRx® products are manufactured utilizing the latest extraction, fermentation and bio-conversion technologies and are particularly appropriated for maintenance, treatment and corrective skin care systems.

DermalRx

 



Biocogent's Pleiotanicals® are high-potency plant-derived pleiotropic (multi-functional) active ingredients. These products are derived from whole plant or specific plant parts (flowers, roots, stems). Utilizing specialized and proprietary extraction techniques, such as clean supercritical fluids and cell rupture extraction and purification, active biomolecules are targeted, gently and efficiently extracted, purified and concentrated for greater activity and stability.


Pleiotanicals

 



Biocogent's Advanced Solutions are ingredients based on unique combinations of biopolymers and active ingredients that provide distinctive benefits and functionality. These products are value driven, providing easy-to-formulate, and proven functional benefits, at a value.


Advanced Solutions

Cogesomes represent a breakthrough technology to effectively deliver the potent beneficial effects of active ingredients to the skin. Biocogent scientists designed and developed a novel and proprietary liposome formulation that encapsulates the active in a manner not previously seen in the skin care community.

Cogesome

Tellirictin® (R10047) is a proprietary clove flower extract containing natural gallate-based pleiotropic compounds (tellimagrandin I and casuarictin) for multi-functional anti-aging performance. Tellirictin® addresses the many signs of aging by delivering brightening, anti-wrinkle, and moisturizing activities, while also protecting the skin from oxidative, inflammatory, proteolytic, and environmental stresses. Applications of Tellirictin® include anti-aging, anti-wrinkle, and skin-brightening regimens, soothing and calming products for sensitive skin, and pre- and post-sun care.

 

Tellirictin® prevents excessive melanin production to combat hyperpigmentation by inhibiting tyrosinase activity as efficiently as beta-arbutin. Tellirictin® protects collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin) from damaging enzymes (MMPs and elastases) associated with environmental stressors such as environmental pollution and UV (sun) exposure. Tellirictin® modulates microRNAs involved in the beneficial regulation of DNA repair, barrier protection, and anti-inflammatory pathways. 


Pleiotanicals® Tellirictin® (R10047)

DermalRx® SRC (R10001) is a yeast-derived oligopeptide that promotes skin renewal by stimulating natural exfoliation via gentle and selective desquamation. Clinical testing demonstrates that DermalRx® SRC enhances exfoliation to reduce skin roughness and improve the appearance of wrinkles in four weeks. DermalRx® SRC gently loosens coarse keratinized cells at the surface, delivering results for applications in anti-aging, anti-wrinkle, anti-blemish, skin brightening, and exfoliation products. DermalRx® SRC is clinically demonstrated to restore skin texture and radiance with documented improvements in the appearance of hyperpigmentation, wrinkles, and other signs of aging. DermalRx® SRC is a selective exfoliant for safe, effective skin renewal.

DermalRx® SRC (R10001)

DermalRx® SRC-R (R10099) is a yeast-derived oligopeptide that promotes skin renewal by stimulating natural exfoliation via gentle and selective desquamation. Clinical testing demonstrates that DermalRx® SRC-R enhances exfoliation to reduce skin roughness and improve the appearance of wrinkles in four weeks. DermalRx® SRC-R gently loosens coarse keratinized cells at the surface, delivering results for applications in anti-aging, anti-wrinkle, anti-blemish, skin brightening, and exfoliation products. DermalRx® SRC-R is clinically demonstrated to restore skin texture and radiance with documented improvements in the appearance of hyperpigmentation, wrinkles, and other signs of aging. DermalRx® SRC-R is a selective exfoliant for safe, effective skin renewal.

DermalRx® SRC-R (R10099)

DermalRx® Acetygen® (R10117) is a botanical active ingredient featuring Agrimonia eupatoria and Ampelopsis grossedentata extract with potent phytochemicals (including dihydromyricetin, myricetin, and other bioactive ﬂavonoids). DermalRx® Acetygen® is a potent senolytic and broad-spectrum epigenetic modulator for applications in skin health and wellness, such as anti-aging products targeting oxidative, environmental, and inflammatory damage. DermalRx® Acetygen® enhances natural skin repair mechanisms to help eliminate dysfunctional senescent cells that contribute to signs of tissue aging. By regulating the histone deacetylase (HAT/HDAC) “switch”, DermalRx® Acetygen® epigenetically restores gene expression to levels found in younger skin for a renewed extracellular matrix (ECM). DermalRx® Acetygen® protects the skin from oxidative stress and inflammatory damage while rejuvenating the tissue for a youthful, healthy appearance. 

DermalRx® Acetygen® (R10117)

DermalRx® CKW (R10091) is a plant-derived combinatorial curcuminoid extract that potently and dose-dependently modulates excess sebum production by inhibiting type I and type II 5α-reductase. Clinical evaluation showed significant reductions in sebum production and a visible decrease in facial sheen. DermalRx® CKW is ideal for sebum-regulating products for skin and hair applications, as well as anti-blemish and pore-minimizing formulations.

DermalRx® CKW (R10091)

DermalRx® HydroSeal (R10067) is a yeast-derived oligopeptide that fortifies the skin barrier functions to restore moisture retention. Clinical testing demonstrates that DermalRx® HydroSeal has impressive moisturizing and anti-wrinkle effects in four weeks. Ideal for applications in anti-aging, anti-wrinkle, moisturization, and skin repair products, DermalRx® HydroSeal rebuilds cell-to-cell junctions for a more compact and less permeable stratum corneum, reducing transepidermal water loss (TEWL) and improving skin hydration. DermalRx® HydroSeal is produced using biofermentation with a proprietary Saccharomyces cerevisiae strain to improve the integrity of the skin barrier for skin moisturization and protection from excessive water loss.

DermalRx® HydroSeal (R10067)

Cogesome® SA (R10126) is a novel and proprietary liposome formulation that encapsulates salicylic acid (SA) for improved long-term stability and pH to near physiological levels, optimal miscibility in aqueous and glycolic systems, and superior penetration into the skin. Cogesome® SA is well suited for formulas to address blemished skin, including spot treatments, cleansing, and clarifying products, and overnight resurfacing treatments, as well as other skin and hair formulas.Cogesome® SA supports superior skin penetration properties without the irritation associated with traditional salicylic acid. Cogesome® SA is stable and soluble in water for easy formulation in aqueous-based formulation systems. Cogesome® SA is a completely liposome-encapsulated salicylic acid with high miscibility and a pH of 6-7.4, close to physiological pH. As such, the incorporation of salicylic acid by Cogesome® SA does not significantly impact the pH of the final formulation. Cogesome® SA is a high-technology solution for blemish-prone skin.

Cogesome® SA (R10126)

Advanced Solutions MariMoist® KPF (R10097) is a sustainable marine biopolymer derived from Chondrus crispus aquatic plants with bio-derived high molecular weight hyaluronic acid (HA), a glycosaminoglycan that is an important natural component of skin. Referred to as the “aloe of the ocean,” MariMoist® KPF is a water-soluble, viscous, hydrocolloid-flowing gel with the highest standards of consistency, quality, and purity.

 

MariMoist® KPF provides water delivery and a unique textural sensation, improving the aesthetic and tactile properties of finished products while helping to build “body” and impart a rich, luxurious feel. MariMoist® KPF has been demonstrated to bind and deliver water for optimal hydration of the skin, scalp, and hair. Acting as a humectant, MariMoist® KPF is an emollient liquid that instantly moisturizes and softens dry skin.

 

Applications for MariMoist® KPF include an emollient and hydrator in skin and hair products and a formulation aid or aesthetic modifier of product viscosity and body. MariMoist® KPF is an excellent base for formulations.


Advanced Solutions MariMoist® KPF (R10097)

Pleiotanicals® Scavenox® HH (R10109) is a highly stable green tea extract with epigallocatechin gallate (EGCG) for long-term antioxidant, anti-inflammatory, and skin-brightening activity. Applications for Scavenox® HH include anti-aging and anti-blemish regimens, skin-brightening and skin tone-balancing systems, and soothing and calming products for sensitive skin.

Scavenox® HH protects the skin from oxidative stress with the demonstrated ability to prevent UV-induced lipid peroxidation and scavenging of singlet oxygen. Scavenox® HH also inhibits inflammatory and proteolytic (MMPs and elastase) damage for protection against UV radiation, pollution, and other environmental stressors. These activities offer skin protection and renewal by preserving collagen and other components of the extracellular matrix (ECM, the structural foundation of the skin). Scavenox® HH prevents excessive melanin production to combat hyperpigmentation by inhibiting tyrosinase activity.


Pleiotanicals® Scavenox® HH (R10109)

Biocogent LLC

Biocogent, LLC utilizes pioneering technology in research, development, and manufacturing to provide innovative, value-driven functional ingredients and services to its customers in the personal care 

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