Capmul® PG-12

Processing Aids

• Direct-compression, free-fraction tablet lubricants which reduce ejection force but allow for faster disintegration times than surface spreading lubricants
• Soft gel lubricants which allow for less washing and ease of capsule printing
• Binder excipients for hot melt granulation and extrusion

Emulsification

• Functional lipids for primary and secondary emulsification of actives
• Emulsifiers and surfactants for the formulation of self-emulsifying drug delivery systems (SEDDS)

Lipid Nanoparticle Delivery Systems

• Functional lipids for the development of solid lipid nanoparticles and nanostructured lipids

Permeation Enhancement

• Functional lipids which can increase the permeation of BCS Class III and BCS Class IV actives
• Increase permeation of polar molecules with functional groups which are ionized at biological pH
• Increase permeation of actives affected by PGP mediated efflux

Controlled Release

• Formulation of both matrix and encapsulated controlled release
• Formulation of controlled release multi-particulates for use in tablet and capsule formulations
• Directly-compressed matrix controlled release tablet formulations

Encapsulation

• Formulation of functional multi-particulates
• Use in both matrix and encapsulated multi-particulates
• Employ in both congealing and molten fluid bed unit operations

• Emulsification
• Transdermal Penetration Enhancer

• Increase the solubility of BCS Class II and BCS Class IV actives
• Increase the bioavailability of poorly water-soluble actives
• Both single lipid and self-emulsifying drug delivery system (SEDDS) formulations of poorly water soluble APIs

USP/NF, FCC, USFA, JSFA, E477