Products in Solvents & Solubilizers: Encapsulation

KLEPTOSE® LINECAPS Pea Maltodextrin Cyclodextrin can be used as a solubilizer, stabilizer and taste-making agent in pharma oral dosage applications. Applications Swallowable, chewable and effervescent tablets Lozenges Hard and soft capsules Orally dissolving films Blends Granules Pellets premix Medicated confectionery Syrups Suspensions Liquids Cream Paste Semi-solids

CLEARGUM® CO 03 is a pregelatinized, low-viscosity octenyl succinate starch that can be used as an emulsifier and solubilizer in pharmaceutical and nutraceutical formulations including encapsulation of vitamins or APIs. and as a binder in wet granulation. Benefits BSE-free Halal and Kosher certified Melamine-free Non-GMO Non-hazardous TSE-free Vegan Features Food modified starch (E1450) Free of off-odors Low viscosity Tasteless

KLEPTOSE® HPB Biopharma Hydroxypropyl Betadex Cyclodextrin is a low endotoxin grade materials that provides protein stabilization for biopharmaceutical downstream applications. With a hydrophobic internal cavity and hydrophilic exterior, KLEPTOSE® HPB BioPharma can encapsulate molecules, forming inclusion complexes where lipophilic compounds are non-covalently bound within the cavity. It is suitable for use in biopharmaceutical manufacturing and as an excipient for injectable dosage forms. Benefits Unique ability to encapsulate and shield water insoluble materials can be utilized to shield exposed hydrophobic residues on aggregation-prone proteins, thereby modulating protein aggregation Shows promise as a multifunctional excipient suitable for biopharma applications Can serve as a tool to synergistically complement biotherapeutic formulations Multicompendial material (EP, USP, JP) Features Starch derivative Cyclic oligosaccharide with a bucket-like structure

KLEPTOSE® HPB Hydroxypropyl Betadex Cyclodextrin is a modified beta-cyclodextrin parenteral grade material that can be used as an encapsulating agent for Rx injectables. Benefits Improves stabilization of active substances against light and oxidation Enhances solubilization of active pharmaceutical ingredients Features White, amorphous powder Molecule is a torus-shaped ring with a polar hydrophilic outside and an apolar hydrophobic cavity

These functional lipid excipients act as solubilizers and emulsifiers in oral drug delivery systems. CAPMUL excipients are recognized as the ideal starting point when formulating BCS Class II & IV (poorly water soluble) and BCS Class III & IV (poorly permeable) molecules. Lipid-based drug delivery systems may be formulated as liquid or semi-solid formulations for oral dosage forms. It is manufactured in USA.

Acconon® MC8-2 EP/NF is a mixture of monoesters, diesters, and triesters of glycerol and monoesters and diesters of polyethylene glycols with a mean relative molecular weight between 200-400. It may contain free macrogols. It is manufactured in USA.

Acconon® C-44 EP/NF is a mixture of monoesters, diesters, and triesters of glycerol and monoesters and diesters of polyethylene glycols with a mean relative molecular mass of 1500. It may contain free macrogols. It is manufactured in USA.

Stearoyl macrogolglycerides are mixtures of monoesters, diesters and triesters of glycerol and monoesters and diesters of macrogols (polyethylene glycols (PEG) with a mean relative molecular mass between 300 and 4000). They are obtained by partial alcoholysis of saturated oils containing mainly triglycerides of stearic acid using macrogol (PEG) or by esterification of glycerol and macrogol (PEG) with saturated fatty acids or by mixture of glycerol esters and condensates of ethylene oxide with the fatty acids of these hydrogenated oils. The product may contain free polyethylene glycols, and appears as a pale-yellow, waxy solid. It is manufactured in USA.