L-HPC

Shin-Etsu Pharma, Nutra and Food Brand

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC.   L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.
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Knowde Brand Summary

Identification

Features & Benefits

Applications & Uses

Knowde Brand Highlights

Key Benefits of L-HPC
  • Higher stability due to its non-ionic nature and low water activity
  • No peroxide offers superior stability
  • Disintegration into smaller particles leading to better dissolution
  • Anti-capping effect for tableting process
  • Suitable for pellet extrusion as well as tableting
  • A variety of grades are available depending on application
Brand Highlights
  • Water insoluble, swells in water and works as dual functional ingredients, 
    disintegrant and binder for tablets and pellets.
  • Suitable grade can be selected depending on process and API characteristics.
  • Non-ionic polymer which has less interaction with API and better stability.