PTSC

PTSC is an intermediate in chemical and pharmaceutical synthesis. Among others it is an activation agent in the synthesis of organic compounds. One major application of PTSC is the tosylation of alcohols in order to activate the group for conversion at a later step in the synthesis. Through the use of PTSC an alcohol can be converted into an excellent leaving group, as depicted in below schema:
R-OH + TsCl → R-OTs + HCl
R-OTs + NH3 → R-NH2 + HOTs
NH3 is taken as example but it can be done with any organic nucleophile.
PTSC is also used to convert carboxylic acids into phenolic esters through the use of the weak nucleophiles like phenols.
Many pharmaceuticals are prepared with PTSC as activating agent as for example:
• Flupentixol (psychiatric drug)
• Thiometon (pesticide)
• Deltamethrine (pesticide)
• Diboc (protecting agent)
• Cefotaxime (antibiotic)
• MDMA (psychiatric drug)

*Little colored spots can be found on the surface of the powder due to moisture condensation.

• 25 kg polyethylene drums, 24 on a pallet.
• 100 kg polyethylene drums, 4 on a pallet.