Products in Excipients: Hot Melt Extrusion

Kolliphor® P 188 micro Geismar is a versatile product that caters to healthcare and pharmaceutical applications, supporting various drug delivery methods like creams, dispersions, emulsions, foams, injectables, soft gels, and transdermal patches.

Kollidon® VA 64 Fine, a copovidone-based product, serves diverse functions in pharmaceuticals and nutraceuticals. As an anti-crystallizing agent, binder, dispersing agent, filler, film former, matrix forming agent, and moisture barrier coating, it plays a pivotal role in drug delivery and care solutions. Its applications extend to oral and topical healthcare formulations, as well as nutrition and well-being products in the food and nutrition industry. With a versatile physical form available as both powder and solid, Kollidon® VA 64 Fine embodies essential technologies for achieving optimal performance in pharmaceuticals and nutraceuticals.

Kolliphor® P 407 micro Geismar is specially designed for healthcare and pharmaceutical applications, this product is suitable for oral and topical use. Kolliphor® P 407 micro Geismar is utilized in formulations such as creams, dispersions, emulsions, foams, gels, and soft gels.

Kollidon® SR, a synthetic ingredient, excels in pharmaceuticals and nutraceuticals as a versatile solution. Serving as a controlled release agent, filler, film former, matrix forming agent, solvent, sustained release agent, and viscosity modifier, it proves indispensable in diverse applications. Found in powder form, it is tailored for healthcare and pharmaceutical needs, specializing in oral and topical drug delivery and care solutions. This innovative technology redefines pharmaceutical formulations, ensuring optimal performance in controlled and sustained release scenarios.

Kollicoat® MAE 100-55 is a versatile pharmaceutical and nutraceutical ingredient. Comprising Acrylates Copolymer and Methacrylic Acid Ethyl Acrylate Copolymer in a 1:1 ratio, it excels as an enteric coating system, filler, film former, matrix-forming agent, and solubilizer. In powder form, this technology caters to oral drug delivery and care solutions. Ideal for healthcare and pharma applications, Kollicoat® MAE 100-55 ensures efficient and reliable performance in diverse formulations.

Kolliphor® P 188 Geismar, a versatile chemical compound also known as poloxamer 188, serves a pivotal role in pharmaceutical and nutraceutical technologies. As a foaming agent, dispersant, gelling agent, lubricant, plasticizer, solubilizer, stabilizer, wetting agent, and emulsifier, it finds application in healthcare and pharma for drug delivery and care solutions. Specifically designed for oral and topical use, Kolliphor® P 188 Geismar ensures optimal performance in diverse pharmaceutical formulations, contributing to the efficacy and reliability of drug delivery systems.

Kollicoat® MAE 100 P is available in powder form, plays a multifaceted role as an enteric coating system, filler, film former, matrix-forming agent, and solubilizer. Its versatile applications span various dosage forms, including tablets, pellets, capsules, soft gels, and dispersions in the healthcare and pharma markets, particularly in oral drug delivery solutions.

Kolliphor® EL, a versatile pharmaceutical ingredient, boasts PEG-35 castor oil as its key component. Functioning as a plasticizer, gelling agent, matrix-forming agent, nonionic surfactant, emulsifier, and solubilizer, it finds applications in healthcare and pharma for drug delivery and care solutions. Ideal for ophthalmic, oral, parenteral, and topical applications, this liquid formulation seamlessly integrates into pharmaceutical and nutraceutical technologies. Offering a reliable solution across diverse domains, Kolliphor® EL stands out for its efficacy and adaptability in the realms of pharmaceuticals and nutraceuticals.

Soluplus® is a graft copolymer comprised of polyvinyl caprolactam, polyvinyl acetate, and polyethylene glycol. It presents as free-flowing granules, ranging from white to slightly yellowish, accompanied by a faint characteristic odor. Designed specifically for solid solutions, this polymeric solubilizer boasts an amphiphilic chemical structure. Its functionalities encompass roles as a bioavailability enhancer, stabilizer, matrix-forming agent, anti-crystallizing agent, film former, filler, and solubilizer. Soluplus® finds application in various forms, including capsules, dispersions, transdermal patches, and tablets. The product adheres to sustainable practices and holds certifications such as China DMF, US DMF, and cGMP compliance.

Kolliphor® ELP is a versatile pharmaceutical excipient featuring PEG-35 castor oil. With its roles as a plasticizer, gelling agent, matrix-forming agent, nonionic surfactant, emulsifier, and solubilizer, it plays a pivotal role in various pharmaceutical and nutraceutical applications. In healthcare and pharma, Kolliphor® ELP excels in drug delivery and care solutions, with applications in ophthalmic, oral, parenteral, and topical formulations. Presented in a convenient paste form, Kolliphor® ELP embodies cutting-edge technologies to meet the dynamic needs of the pharmaceutical industry.

Kolliphor® SLS Fine is a versatile sodium lauryl sulfate powder designed for pharmaceutical and nutraceutical applications. Serving as a plasticizer, gelling agent, matrix-forming agent, dispersant, surfactant, solubilizer, emulsifier, wetting agent, and lubricant, it plays a crucial role in drug delivery and care solutions. Ideal for oral and topical formulations, Kolliphor® SLS Fine excels in healthcare and pharma technologies, providing reliable performance in various pharmaceutical applications.

Kolliphor® HS15 is a yellowish white paste at room temperature that becomes a liquid at approximately 30°C. It dissolves in water, ethanol and 2-propanol to form clear solutions. Its solubility in water decreases with increasing temperatures. It is insoluble in liquid paraffin.

Kolliphor® ELP is a white to yellowish paste or cloudy liquid. It is a non-ionic solubilizer made by reacting castor oil with ethylene oxide in a molar ratio of 1:35. This is followed by a purification process. Kolliphor® ELP forms clear solutions in water and also dissolves in a wide range of organic solvents, such as ethanol, n-propanol, isopropanol, ethyl acetate, chloroform, carbon tetrachloride, trichloroethylene, toluene and xylene.

Kollicoat® Smartseal 100 P is a spray dried powder of a methyl methacrylate (MMA)and diethylaminoethyl methacrylate (DEAEMA) copolymer. The molar ratio of the monomers MMA and DEAEMA in the copolymer is 7:3. The powder contains approx. 2% macrogol cetostearyl ether and approx. 2.5% sodium lauryl sulfate. It is white and has a pleasant characteristic odor.

Kollicoat® MAE 100-55 is a white redispersible powder with a faint characteristic odor. The product contains 0.7% sodium lauryl sulfate (USP) and 2.3% Polysorbate 80 (Ph. Eur.) as emulsifying agents. The fatty acids used in the manufacture of Polysorbate 80 are of vegetable origin. Kollicoat® MAE 100-55 is a weakly acidic copolymer that dissolves at a pH above 5.5. Kollicoat® MAE 100-55 dissolves in methanol and ethanol to yield clear to slightly cloudy solutions. It is also soluble in dilute alkaline solutions.

Kollisolv® PEG 1000 is a white to almost white solid with a waxy or paraffin-like appearance. It is very soluble in water, freely soluble in alcohol, practically insoluble in fatty oils and in mineral oils.

Kollidon® VA 64 is a white or slightly yellowish, free-flowing powder with a faint characteristic odor and practically no taste. It readily dissolves in all hydrophilic solvents. Solutions of more than 10 % concentration can be prepared in water, ethanol, isopropanol, methylene chloride, glycerol and propylene glycol. It is less soluble in ether, cyclic, aliphatic and alicyclic hydrocarbons.

Kolliphor® P 407 Micro Geismar is supplied as white to slightly yellowish microbeads. It is readily soluble in water and ethanol and other mainly polar solvents. It is insoluble in ether, paraffin and fatty oils. It offers effective content uniformity, solubilization and increase oral bioavailability of bioactive

Soluplus® is a polymeric solubilizer with an amphiphilic chemical structure, which was particularly developed for solid solutions. Due to its bifunctional character, it is able to act as a matrix polymer for solid solutions on the one hand, and, on the other hand, it is capable of solubilizing poorly soluble drugs in aqueous media. Furthermore, Soluplus® can increase the bioavailability of poorly soluble drugs.

Kolliphor® P 188 Micro Geismar is supplied as white to slightly yellowish microbeads. It is readily soluble in water and ethanol and other mainly polar solvents. It is insoluble in ether, paraffin and fatty oils.

Kollidon® SR is a mixture of 80% of polyvinyl acetate and 19% povidone (Kollidon® 30) in a physical mixture. Approximately 0.8% of sodium lauryl sulfate and about 0.2% of silica are used as stabilizers. It is supplied as slightly yellowish, free-flowing powder. Kollidon® SR Polymer is insoluble in water and very soluble in N-methylpyrrolidone.

Kolliphor® PS 80 is an amber liquid with a faint characteristic odor. Kolliphor® PS 80 is used as a non-ionic surfactant and oil-in-water emulsifier, as plasticizer in a range of solid dispersions and oral dosage forms. It is a non-ionic, hydrophilic emulsifier with broad pH range applicability and good skin tolerance in topical formulations.

Kolliphor® SLS Fine is a white to off-white powder with faint characteristic odor. The product tends to agglomerate. The agglomerates exhibit a yellowish to brownish color and are completely soluble by heating and stirring. Solubilizing, the agglomerates does not influence the product quality. The product is characterized by a very high active substance matter and a very low content of inorganic salts and unsulfated fatty alcohol. Preferred areas of application are pharmaceutical emulsion, tablets and cream shampoos.

POLYOX™ WSR N - 750, available in a white to off-white free-flowing powder with a distinctive ammoniacal odor, exhibits water solubility. Its applications in cleaning include functioning as a binder and thickener, with manufacturing often utilizing hot melt extrusion technology for its production, maintaining its physical form as a powder throughout.

ETHOCEL™ Standard 7 Premium Ethylcellulose White Powder has binding, controlled release, flexibility, and thermal stability benefits. It's soluble in organic solvents and ethanol. Used in direct compression, encapsulation, granulation, hot melt extrusion, and tablet coating. It functions as a controlled release agent, granulation aid, and taste masking agent.

ETHOCEL™ Standard 100 FP Premium Ethylcellulose a white powdered ethylcellulose variant, boasts benefits such as controlled release, excellent flexibility, and thermal stability. Its utility extends to cosmetic applications, where it functions as a stabilizer and thickener. Its manufacturing technology includes direct compression, encapsulation, granulation, and hot melt extrusion processes.

ETHOCEL™ Standard 20 Premium Ethylcellulose White powder for binding, controlled release, flexibility, and thermal stability. Ideal for hot melt coating tablets, it is soluble in organic solvents and ethanol. It aids in granulation and acts as a taste masking agent. Suitable for direct compression, encapsulation, granulation, hot melt extrusion, and tablet coating.

POLYOX™ WSR N - 12K an off-white powder, finds application in abuse deterrent tablets, gels, and osmotic pump tablets. Employing hot melt extrusion technology, it exhibits material features like flexibility, good toughness, grease and oil resistance, and viscoelastic properties. Additionally, it boasts water solubility.

ETHOCEL™ Standard 14 Premium Ethylcellulose available in powder form, is adaptable for various manufacturing processes such as direct compression, encapsulation, and granulation. It exhibits ethanol solubility, offering versatility in pharmaceutical and industrial applications.

ETHOCEL™ Standard 10 FP Premium Ethylcellulose a white powder, boasts various benefits such as binding, controlled release, excellent flexibility, and thermal stability. It is manufactured using techniques like direct compression, encapsulation, granulation, and hot melt extrusion. Additionally, it exhibits solubility in ethanol and organic solvents.

ETHOCEL™ Standard 4 Premium Ethylcellulose is a white powder that is soluble in ethanol and organic solvents. It provides benefits such as binding, controlled release, excellent flexibility, and thermal stability, making it highly suitable for various industrial applications where these properties are critical.

ETHOCEL™ Standard 45 Premium Ethylcellulose with its white color and powder form, offers versatile applications in tablet manufacturing. Its benefits include binding and controlled release properties, along with excellent flexibility. Utilizing direct compression or encapsulation techniques, it enables hot melt coating and is soluble in ethanol, organic solvents, and isopropanol.

ETHOCEL™ Medium 50 Premium Ethylcellulose offers binding, controlled release, flexibility, and thermal stability. It serves as a stabilizer and thickener in cosmetics. Compatible with various manufacturing processes like direct compression, encapsulation, granulation, hot melt extrusion, and tablet coating. It dissolves in organic solvents like ethanol and isopropanol.

POLYOX™ WSR - 301 a white powder, is used in gels, osmotic pump tablets, and regular tablets. It offers viscoelasticity, lubricity, and a silky feel, making it suitable for sprayers, tissue, and toweling. It's water-soluble, compatible with polystyrene and polycaprolactone, and non-toxic.

POLYOX™ WSR N - 750 Amerchol is a white to off-white free-flowing powder with a characteristic ammoniacal odor. It exhibits water solubility, making it suitable for various dosage forms like gels, osmotic pump tablets, and tablets. Its industrial applications include serving as a binder in paper tissue and paper towel production and being utilized in plastics and elastomers for molded combs and seed tape.

Affinisol™ HPMC HME 15LV is a versatile polymer used in hot melt extrusion and spray drying manufacturing technologies. It is soluble in both water and organic solvents, making it ideal for a variety of pharmaceutical formulations, enhancing solubility and stability.