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L-HPC LH-11

L-HPC (low-substituted hydroxypropyl cellulose NF, JP, EP) This dual functioning excipient acts as both a disintegrant and binder. It is not the same as HPC. L-HPC is insoluble in water. It is an effective disintegrant due to its swelling action in water. Because is has good compressibility, it functions as a dry binder.L-HPC benefits are:Enhanced stability because it is non-ionic and has low water activityIt is peroxide free and provides excellent compatibility for oxygen sensitive APIsImproved disintegrationA variety of grades are available depending on the application.L-HPC LH-11 is suitable for direct compression and prevents capping during compression.

Brand: L-HPC (11 products)

Chemical Name: Low-Substituted Hydroxypropyl Cellulose

Functions: Binder, Disintegrant, Dispersant

Dosage Form: Capsules, Pellets, Tablets

Labeling Claims: Allergen-free, BSE-free, Kosher, Non-GMO, Solvent-free, TSE-free

Certifications & Compliance: DMF Type IV, European Pharmacopeia (Ph. Eur.), GMP, Japan Pharmacopeia (JP), Kosher, National Formulary (NF), The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA)

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Chemical Name: Low-Substituted Hydroxypropyl Cellulose
Pharma & Nutraceuticals Functions: Binder,
Disintegrant,
Dispersant
CAS No.: 9004-64-2
EC No.: 618-388-0
Technologies: Pharmaceuticals & Nutraceuticals
Product Families: Pharmaceuticals & Nutraceuticals — Excipients
Binders & Disintegrants,
Formulation & Processing Aids
Structure

Features & Benefits

Labeling Claims: Allergen-free,
BSE-free,
Kosher,
Non-GMO,
Solvent-free,
TSE-free
Features: Water insoluble, swells in water and works as dual functional ingredients, disintegrant and binder for tablets and pellets.

Suitable grade can be selected depending on process and API characteristics.

Non-ionic polymer which has less interaction with API and better stability.

Applications & Uses

Markets: Healthcare & Pharma
Applications: Healthcare & Pharma — Drug Delivery & Care Solutions
Oral
Healthcare & Pharma — Pharmaceutical Manufacturing
Excipients & Coatings
Dosage Form: Capsules,
Pellets,
Tablets
Manufacturing Technology: Capsule Filling,
Direct Compression

Properties

Physical Form: Powder,
Solid
Typical Properties
Particle Size Distribution
Note: *In-house Laser diffraction method

Regulatory & Compliance

Certifications & Compliance: DMF Type IV,
European Pharmacopeia (Ph. Eur.),
GMP,
Japan Pharmacopeia (JP),
Kosher,
National Formulary (NF),
The Food Allergen Labeling & Consumer Protection Act of 2004 (FALCPA)
Chemical Inventories: AICS (Australia),
DSL (Canada),
ENCS (Japan),
IECSC (China),
KECI (Korea),
NZIoC (New Zealand),
PICCS (Phillipines),
TCSI (Taiwan),
TSCA (USA)
Grade: Pharma Grade

Technical Details & Test Data

Pictures of Aspirin Tablets with Various Excipients (After stability test): Aspirin tablets with 20% excipients were stored in closed plastic bottle at 50°C for 3 months.
Anti-Capping Effect of L-HPC: Ethenzamide tablets were prepared with various ratio of excipients and friability test was implemented in accordance with USP method.

Packaging & Availability

Packaging Type: Bags,
Drums
Package: 50 kg - Fiber drum with polyethylene double bag inside

1 kg - Polyethylene double bag

Storage & Handling

Storage: Keep dry. Store away from excess heat and sunlight. Store in sealed containers.