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Proxel® TN Preservative

Proxel® TN Preservative is a dual active, broad spectrum biocide for the preservation of industrial water-based products against spoilage from bacteria, yeasts and fungi. It is a 55% aqueous solution of 1,2-benzisothiazolin-3-one (BIT) and hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine, a formaldehyde release agent. It is effective in a wide range of industrial aqueous-based products. The combination of two active agents provides a quick microbial kill with long term protection. The “triazine” active agent gives enhanced head space protection in the container.

Brand: Proxel (25 products)

Functions: Anti-Microbial Agent, Anti-Microbial Agent, Bactericide, Biocide, Preservative

Features: Bacteria Resistance, Fungal Resistance

Synonyms: 1,2-Benzisothiazol-3-one, 1,2-Benzisothiazolin-3-one, 1,2-Benzisothiazolone, 1,2-Benzoisothiazol-3-one, 1,2-benzothiazolin-3-one, 1,2-benzothiazoline-3-one, 2,3-Dihydro-1,2-benzothiazol-3-one, 2,3-Dihydrobenzisothiazol-3-one, 3-Hydroxy-1,2-benzisothiazole, Benzisothiazolin-3-one, Benzisothiazolinone, Benzisothiazolone, Benzo[d]isothiazol-3(2H)-one, Benzoisothiazol-3-one

Enhanced TDS

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Carrier
CAS No.
2634-33-5
EC No.
220-120-9
Chemical Structure

Proxel® TN Preservative - Chemical Structure

Composition

An aqueous solution of 1,2-benzisothiazolin-3-one and hexahydro-1,3,5-tris(2 hydroxyethyl)-s-triazine

Features & Benefits

CASE Ingredients Features

Applications & Uses

Applicable Processes
Adhesive & Sealant Type
Coating Type
Use Level
0.01-0.30%
Applications

The product is effective in a wide range of industrial aqueous-based products. The combination of two active agents provides a quick microbial kill with long term protection. In addition, the “triazine” active agent gives enhanced head space protection in the container. Application areas include:

  • Synthetic polymer emulsions
  • Emulsion paints
  • Aqueous pigment dispersions
  • Water-based adhesives
Amount to Use

Table 3. Applications

Product % PROXEL™ TN Preservative (w/w)
Emulsion Paints 0.05-0.2
Pigment dispersions: based on slurries 0.05-0.2
Synthetic polymer emulsions 0.05-0.2
Water-based adhesives 0.05-0.15

 

PROXEL™ TN Preservative should be added to the system as early in the process as possible but only after all heating stages are completed and the temperature of the product is less than 40°C. The concentration required to adequately preserve your product depends on several factors. These include the susceptibility of the system to microbiological degradation, the extent to which micro-organisms can gain access, the species involved, pH, temperature, and length of time for which protection is required.


A range of concentrations and applications is recommended in Table 3; however, it is recommended that a testing program be undertaken to determine the most costeffective dose for your application.


Testing should take into account chemical compatibility/stability, plant hygiene conditions, susceptibility of the product to contamination, and the typical organisms involved.

Properties

Physical Form
Soluble in
Water
Typical Physical Properties
ValueUnitsTest Method / Conditions
pH Value (25°C)12--
Viscosity (at 10/25°C)180/60mPasNewtonian
Boiling Point110°C
Flash PointBoils without flashing°C
Density (at 25°C)1.13
Minimum Inhibitory Concentrations (MIC)

Table 1.

Micro-organism PROXEL™ TN Preservative (ppm)
Bacteria  
Bacillus subtilis 100
Enterobacter cloacae 150
Escherichia coli 100
Proteus vulgaris 175
Pseudomonas aeruginosa 200
Pseudomonas putida 200
Staphylococcus aureus 100
Strephylococcus faecalis 100
Strephylococcus lactis 100
Fungi  
Alternaria alternata 1000
Aspergillus niger 500
Aureobasidium pullulans 750
Chaetomium globosum 500
Cladosporium cladosporioides 600
Penicillium notatum 300
Yeasts  
Candida albicans 150
Rhodotorula rubra 200
Saccharomyces cerevisiae (turbindans) 150

 

Antimicrobial Properties

The levels of product needed to prevent the growth of problem microorganisms are listed in Table 1; Minimum Inhibitory Concentrations (MICs) do not represent effective use levels but do indicate the broad spectrum of activity.

PROXEL™ TN Preservative has a non-specific mode of action which means that bacterial resistance is very unlikely to occur. Detailed information on the mode of action is available on request.

Active Agent

50% w/w “triazine” and 5.5% w/w 1,2-benzisothiazolin-3-one

Compatibility

Compatible and effective over pH range 4-12. Stable in the presence of amines.
Incompatible with some oxidizing and reducing agents e.g. persalts, sulphites etc.

Regulatory & Compliance

Certifications & Compliance
Total Quality

Lonza Microbial Control holds a number of ISO 9001 Quality Management registrations covering our product range. The scope of each registration is specific to the location or entity named on the Registration Certificate and our products are supplied to ISO 9001 Standards.

Regulatory Information

The components of PROXEL™ TN Preservative are in compliance with the following inventories:

  • EINECS (Europe)
  • TSCA (USA)
  • AICS (Australia)
  • ENCS (Japan)
  • DSL (Canada)
  • KECL (Korea)
  • PICCS (Philippines)
  • IECSC (China)

Safety & Health

Risk Assessment and Management

Lonza professionals have a wide expertise in the fields of Safety, Health and the Environment. Lonza Microbial Control is committed to and uses this expertise in understanding the suitability of PROXEL TN Preservative for specific applications

Packaging & Availability

Regional Availability
  • Africa
  • China
  • Europe
  • India
  • Japan
  • Latin America
  • Middle East
  • North America
  • Oceania
  • South East Asia

Storage & Handling

Storage & Stability

Stable under normal conditions of storage down to -10°C. If frozen, allow to thaw and stir well before use.