Excipient MultiFunctional C

With n = 6, the number in the name of the product indicates its average molecular weight.

• The low-molecular weight liquid polyethylene glycols Kollisolv® PEG 300 is excellent solvent for a large number of substances that do not readily dissolve in water. It’s widely used as solvent and solubilising agent for active substances and excipients in liquid and semi-solid preparations. It is the ability of PEGs to form complexes with active substances that is responsible for their excellent solvent power.
• However, equilibrium constants for complex formation vary considerably from one substance to another, and certain drugs such as Penicillin G and Bacitracin can even become inactivated.
• The effect of the polyethylene glycol on the efficacy and absorption of a drug must therefore always be determined in tests. With regard to incompatible substances, please see the remarks in the European Pharmacopeia, Vol. II/3, Monographs M1, Macrogol 300, p. 3.
• Polyethylene glycols can also be used to adjust the viscosity of liquid pharmaceutical preparations and ointments, to modify their absorption properties and to stabilize the preparation. In the manufacture of soft gelatin capsules, liquid macrogol can be used as carrier for dissolved or suspended drugs.
• Mixtures of solid and liquid polyethylene glycols can be used as water-soluble bases for ointments, suppositories and ovula. For burns from chlorophenols or chlorocresols, a mixture of two parts Kollisolv® PEG 300 and one part ethanol is recommended.

Hygroscopicity

At room temperature and 80% r. h. approx. 55% of increase of weight was noted over a period of 42 days.

Viscosity

Temperature: 20 °C – 80 °C
GP: 500 1/s

Dynamic viscosity of Kollisolv® PEG 300

• 130 kg Plastic drums
• 0.5 kg Plastic bottle