SP Veterinaria Fluquinol

Oral administration: Dilute the required amount of drug in water, shake until a homogeneous solution is obtained and administer to the animals.

• Chickens and Turkeys: 12-24 mg of drug/kg bw (equivalent to 1 ml of drug per 4-8 kg bw) per day, for 3-5 consecutive days.
• Pigs:
  • Adults: 6 mg of drug/kg bw (equivalent to 3 ml of drug per 50 kg bw) every 12 hours, for 3-5 consecutive days.
  • Piglets: 12 mg of medicine/kg of bw (equivalent to 3 ml of medicine per 25 kg of bw) every 12 hours, for 3-5 consecutive days.
• Calves: 5-10 mg of medicine/kg bw (equivalent to 1.25-2.5 ml of medicine per 25 kg bw), every 12 hours for 5 consecutive days.
• Lambs and kids: 6 mg of drug/kg bw (equivalent to 1.5 ml of drug per 25 kg bw), every 12 hours for 4-6 days

• Poultry (broilers and turkeys): Colibacillosis, salmonellosis, pasteurellosis.
• Pigs: colibacillosis, enteritis, gastroenteritis, neonatal diseases.
• Lambs and kids: Colibacillosis, septicemia, pasteurellosis, enzootic pneumonia.
• Calves: Bronchopneumonia, colibacillary enteritis, neonatal diseases, salmonellosis

• Meat: 10 days
• Milk: do not use
• Eggs: do not use

Pharmacodynamic Properties:

Flumequine is an antibacterial agent belonging to the group of fluoroquinolones with bactericidal activity that acts by inhibiting DNA gyrase, an enzyme involved in the formation of the DNA helix. It has a narrow spectrum of action that essentially covers Gram negative bacteria. Bacterial resistance to flumequine, as in the rest of the quinolones, normally occurs due to the alteration of DNA-gyrase (Topeither isomerase II) by mutation of the Gyr-A subunit and less frequently by mutation of the ParC subunit (Topoisomerase IV). Other resistance mechanisms appear when the bacterium decreases the permeability of its membrane, thus preventing the passage of the antibacterial or increasing the active transport of the compound out of the cell. Cross-resistance among antimicrobials of the quinolone class is common.

Pharmacokinetic Data:

After oral administration, 10% of the dose is absorbed, reaching the maximum plasma concentration after 2 hours. It is widely distributed in tissues. Plasma protein binding is 74.5%. Unchanged flumequine and its hydroxylated metabolite, which has less activity, are found in the blood. 40-60% of the absorbed dose is excreted as unchanged drug in the urine and the remainder as the inactive glucuroconjugate metabolite. A small portion is excreted in the feces.