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SEPPIC INC Madecassoside

Madecassoside is a powerful soothing dermo-cosmetic active for atopic & psoriasis prone skin, made of highly purified Centella asiatica. It is an active ingredient for use in anti-aging, sensitive skin, very dry skin and mature skin applications. Madecassoside activates collagen expression, it provides normalization of hyperproliferation of keratinocytes, global anti-inflammatory properties and a visible effect on excessive desquamation.

INCI Name: Madecassoside

Ingredient Origin: Natural Origin, Plant Origin

Functions: Anti-Aging Agent, Moisturizing Agent, Soothing Agent

Labeling Claims: Clean at Sephora, Preservative-free, Ulta Beauty's Conscious Beauty

Benefit Claims: Anti-Aging, Anti-Inflammatory, Anti-Itching, Anti-Peeling, Antioxidant Properties, Comforting, Healing, Moisturizing, Redness Reduction, Regenerating, Repairing, Skin Barrier, Soothing

Synonyms: Dimethyl Silicone Polymer With Silica, Asiaticoside A

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Active Component
Madecassoside
Chemical Family
Silicates
Chemical Name
Siloxanes and Silicones, di-Me, reaction products with silica
INCI Name
Madecassoside
Ingredient Origin
Natural Origin,
Plant Origin
Cosmetic Ingredients Functions
Anti-Aging Agent,
Moisturizing Agent,
Soothing Agent
CAS No.
67762-90-7
EC No.
614-122-2
Technologies
Cosmetic Ingredients
Product Families
Cosmetic Ingredients — Cosmetic Actives
Skin Actives
Cosmetic Ingredients — Functionals
Conditioners & Emollients,
Sensory Modifiers
Cosmetic Ingredients — Vitamins, Extracts & Oils
Botanical Ingredients & Extracts

Features & Benefits

Benefit Claims
Anti-Aging,
Anti-Inflammatory,
Anti-Itching,
Anti-Peeling,
Antioxidant Properties,
Comforting,
Healing,
Moisturizing,
Redness Reduction,
Regenerating,
Repairing,
Skin Barrier,
Soothing
Labeling Claims
Clean at Sephora,
Preservative-free,
Ulta Beauty's Conscious Beauty

Applications & Uses

Markets
Personal Care
Applications
Personal Care — Beauty & Care
Bath & Shower,
Hair Care,
Skin Care,
Treatment Products
Application Format
Creams,
Gel,
Leave On,
Lotions,
Masks,
Ointments,
Rinse Off,
Serum
Hair Care Applications
Shampoos & Rinses
Skin Care Applications
Anti-Aging Products,
Face Cream,
Facial Mask,
Facial Moisturizer,
Hand Cream,
Moisturizers
Treatment Product Applications
Eczema Treatment
Use Level
0.2-0.5%
Mode of action

- ECM restructuration (Col I & Col III up to +49%)

- Respect of essential cell functions (TNF-α & NFkB activation; SKALP: -60%; free radicals: -70%)

- Normalization of keratinocytes hyperproliferation

- Soothing effect (MMP-1: -61%)

Properties

Physical Form
Powder,
Solid
Soluble in
Water
Typical Properties
ValueUnitsTest Method / Conditions
Puritymin. 95%-

Technical Details & Test Data

Efficacy Studies

- Itching sensation   -65%

- Erythema reduction   -25.7%

- Desquamation area reduction-  43.5%

- Efficacy on atopic / psioriasis-prone skin from D14:

- Soothing effect (Inflamm’Aging) / itching reduction up to 70%

- Anti-redness (erythema reduction up to -25,7%)

- Moisturizing effect (desquamation & PASI score reduction -43.5%)

- Smoothing effect (Roughness score)