Nanovetores Tecnologia S.A. NV R-Growth Hair

Glycerin, Hydrolyzed Pea Protein, European Larch and Green Tea extracts, Glycine and Zinc.

• Reactivates the hair growth cycle.
• Helps to reduce hair loss.
• Contributes to nurture the hair follicle.
• Stimulates cell proliferation of hair follicle stem cells.
• Cell anti-apoptosis effect (cell death).
• Increases hair density on the scalp.

• Stability improvement
• Increased compability in the formulation
• Increased skin permeation
• Reduced dose
• Increased solubility
• Prolonged release
• Increased effectiveness
• Occulsion of odors
• Use of sensitive active ingredients (without refrigeration)

• Active Ingredient Protection against oxidation resulted from interaction with external environment and other components of the cosmetic formulation.
• Monodispersity, that ensures control of the particle size, providing adequate permeation to its proposed action.
• Secure particles larger than 200nm, biocompatible and biodegradable.
• Greater Permeation on the contact surface due to the small size of the capsule.
• Surface Charge Control of the particle, promoting greater affinity with the contact surface.
• Water Base Active ingredients are manufactured without the use of organic solvents, ensuring safety for users and the environment.

NV R-Growth Hair is a powerful active ingre- dient that quickly reactivates a new hair growth cycle and reduces hair loss, in addi- tion to strengthening hair strands and replacing essential vitamins and amino acids for their growth.

The blend can be incorporated into formulations for cosmetics, such as shampoos, conditioners, lotions, and aqueous serums. The product's natural features and non-existent toxicity allow its daily use, delivering effectiveness safely.

Hair

Hair is basically composed of keratin, a protein characterized by its high sulfur con- tent derived from cystine. This protein forms a network of crossed links through disulfide bonds, giving the hair a certain mechanical and chemical resistance (Figure 1). Thus, many hair morphological structures vary their physical and chemical characteristics because of the content of sulfur bridges.

Figure 1: Illustration of control over the surface charge of the capsules, active ingredients for hair products have the capsules with a positive surface charge to be attracted to the hair's natural negative charge.

Hair Cycle

The hair follicle is an anatomical structure normally composed of a hair strand, and its main function is hair growth. Figure 2 shows the structure of the skin hair follicle.

To produce new hair, the existing follicles go through a cycle, divided into three phases: anagen (growth), catagen (transition) and telogen (fall), as shown in Figure 3. This cycle takes from 2 to 7 years.

Anagen is the hair's active phase or growth phase. Dead cells are excreted out of the hair bulb as the hair strand grows back. This phase can last from 2 to 6 years.

After the growth phase, the hair enters the transition or resting phase (catagen). During this phase, the hair is kept in the hair follicle, however the growth phase is suspended, and the hair root is shed. This phase lasts around 2 to 3 weeks.

Finally, the follicle enters its resting stage, the telogen phase, where the hair is shed and falls from the hair follicle. This phase lasts around 3 months, and the follicle remains inactive during this time. Then, the cycle is restarted by the anagen phase again.

Figure 2: Structure of the hair follicle.

Figure 3: Representation of the hair cycle.

Hair Loss and Stem Cells

A scalp has an average of 110,000 hair follicles that are constantly growing and falling. When there is an imbalance between growth and fall, hair loss is accentuated, and baldness begins. This phenomenon is called alopecia. In this hair loss process, the telogen phase is prolonged and the transition to the anagen phase becomes increasingly difficult.

This phenomenon occurs because hair follicle stem cells (ORSc - outer root sheath cells) are less productive and less adapted to improve the quality of the matrix that supports hair growth in the hair follicle. Moreover, fibro- blasts located in the dermal papilla (HFDPc - Human Hair Follicle Dermal Papilla Cells) are less able to communicate with stem cells, causing the matrix renewal to fail, making the anagen phase slower and hair loss occurs daily.

Emulsions in general, gels, cream gels, creams, serums, conditioners, and shampoo.

Emulsions in general, gels, cream gels and serums.

Ethanol and other organic solvents.