Miwon Commercial Company Ltd. Dermapep

DermaPep™ A610 is a hexapeptide, which can inhibit or reduce neurotransmitter release by blocking or destabilizing the formation of SNARE complex that mediates neuronal exocytosis. Therefore it can decrease muscle movement, resulting in a smoother, more relaxed skin surface.

DermaPepTM Youcel shows real effect on hydro-lifting as well as skin brightening. This product is a blend of 5 super powerful peptides in golden ratio. DermaPep TM 350, known as retinoic acid like peptide, shows anti-wrinkle. DermaPep TM 420, a TGF-beta mimic, gives effect on regeneration and anti-aging of skin. DermaPep TM 440, known as collagen protector, inhibits collagen breakdown by suppressing collagen-degrading enzyme (MMPs). DermaPep TM 510, a collagen producer, induces collagen production. DermaPep TM UL, a skin brighter, lighten up your skin by inhibiting melanin production in melanocyte under the skin.

DermaPep™Pepanagen is developed as a safe, low-priced, and highly effective hair nutrition, anti-hair loss and hair growth stimulating agents as the ingredients for topical formulations. DermaPep™Pepanagen prolongs the anagen phase and delays the entry toward the catagen phase by promoting the proliferation of dermal papilla cells, fibroblasts, and keratinocytes and by increasing melanin production. In vivo study results show that DermaPep™Pepanagen inhibits hair loss, strengthens hairs and promotes hair regrowth eventually.

DermaPep™ W411, composed of Methyl undecenoyl leucinate; potent MC-1R specific antagonist, and DermaPep™ W650; potent ETBR specific antagonist, works synergistically to inhibit melanogenesis in human skin. In vitro study results showed that both actives effectively inhibit UV-induced expression and production of tyrosinase, tyrosinase activity and finally melanin production. In vivo clinical study proved that DermaPep™ W411 is very effective agent to make your skin safer and brighter.

Dermapep™ A350 has been demonstrated in vitro by measuring MMP1 production on Hs68 fibroblast cell line.DermapepTM A350 significantly decreased MMP-1 production under both non-stimulated and UV-stimulated condition. Dermapep™ A350 also considerably restored the production of type I procollagen from UVA induced damage (supplementary data were not shown).

ACE inhibitor; improve lymphatic drainage and reduces the formation of eye bags and dark circle. Anti-aging, Eye-bag, Dark circle treatment.

DermaPep™ A4000 is a mixture of DermaPep™ A420 and DermaPep™ A510. The former is a mimic peptide of TGF-β and the latter a pentapeptide fragment derived from collagen type I. DermaPep™ A420 plays a prominent role in the accumulation of ECM components by increasing expression of ECM genes such as collagen and fibronectin. DermaPep™ A510 stimulates the synthesis of collagen type I and Ⅳ. In vivo and in vitro study results show that DermaPep™ A4000 works synergistically to fight against aging. There was an excellent improvement in terms of reduction of fine lines and wrinkles by DermaPep™ A420 and a decrease of wrinkle depth and volume by DermaPep™ A510 in vivo. Surprisingly, the combination of both peptides showed more profound effect on collagen synthesis than either peptide alone in vitro. DermaPep™ A4000 is therefore effective and powerful tools to maintain skin dermal thickness and to fight against signs of aging.

Inhibits S. aureus and other bacteria, fungi in the skin surface of AD patients. Anti-microbia.

DermaPep™ T430 acting as MC1R agonist,activities certain genes involved in the process of pigmentation. Furthermore,DermaPep™ T430 reduces UVB induced inflammation and thereby provides significant photoprotective effect.

DermaPep™ UL interacts with MC1R,a receptor for alpha-MSH,competes against its natural ligand,alpha-MSH and therby prevents any further activation of melanogenic genes such as tyrosinase,TRP1,TRP2(DCT),MITF and POMC and Finally blocks melanin synthesis.

Mimic peptide of enkephalin; reduces the frequency of muscle contraction and thereby prevents the formation of wrinkles and limes. Anti-aging, Anti-wrinkle.

Fragment of IgG, Mimic peptide of DHEA; provides the skin’s elasticity around the eye contour area and reduces eye circles and swollen eyes. Anti-aging, Anti-inflammatory, Eye treatment.

DermaPep™ A420, a mimic peptide of TGF-β, acts via TGF-β signaling pathway and thereby up-regulates ECM proteins such as collagen and fibronectin.

DermaPep™ A440, innovative anti-aging tetrapeptide, has been developed to maximally and effectively inhibit these matrix degrading MMPs and to restore collagen-levels back to normal. In vitro results show that DermaPep™ A440 greatly inhibited the expression and production of MMP-1 under both UV-stimulated and non-stimulated condition and restored collagen levels significantly. In addition, DermaPep™ A440 considerably lowered the MMP levels that have been produced by ROS or RNS. Finally, in vivo clinical study results prove that DermaPep™ A440 is surely one of the best anti-aging agents in the market

DermaPep™ A510 is a peptide fragment derived from collagen type I with N-terminal being modified with palmitoyl group in order to enhance its permeability into skin. DermaPep™ A510 was shown to stimulate the synthesis of collagen type I, IV and glycosaminoglycan (GAG). For this reason, DermaPep™ A510 will provide elasticity to skin and reduce the aging effects.

A mixture of acetyl hexapeptide-8 and pentapeptide-3; works synergistically to prevent the formation of eye bags and dark circle under the eyes. Anti-aging, Anti-wrinkle, Anti-inflammatory.

DermaPep™ A530 represents the most effective active ingrediants for irritated and sensitive skin.it greatly reduced inflammatory cytokines expressions and productions in vitro,especially IL-1α,IL-8 and TNF-α, three most important cytokines that have been known to cause skin irritations.DermaPep™ A530 also clincally proved to reduce skin inflammation and irritation.