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MacDerma™ CSA

MacDerma™ CSA can be obtained by the bark of willow trees. MacDerma™ CSA, or 2-hydroxyl-5-octanoyl benzoic acid is a lipophilized derivative of salicylic acid. The compound has corneolytic, anti-inflammatory, anti-microbial and anticomedonic activities.

Brand: MacDerma (5 products)

INCI Name: Capryloyl Salicylic Acid

Functions: Anti-Inflammatory, Anti-Microbial Agent, Anti-Wrinkle Agent, Comedolytic Agent, Exfoliant (Chemical), Lightening Agent

Ingredient Origin: Synthetic

Labeling Claims: 1,4-Dioxane-free, Allergen-free, Animal Products-free, BSE-free, Bisphenol A-free, Butylated Hydroxyanisole-free, CMR Substances-free, Clean at Sephora, Formaldehyde-free, Fragrance-free, Gluten-free, Glycol ether-free, Hormones-free, Latex-free, Nanomaterials-free, Nitrosamines-free, Non-GMO, Non-Phenolic, Not Listed In California Proposition 65, Not Tested on Animals, Odor-free, Palm Oil-free, Palm free, Paraben-free, Petrochemical-free, Phthalates-free, Silicone-free, Soy-free, Sulfate-free, TSE-free, Talc-free, Ulta Beauty's Conscious Beauty

Benefit Claims: Anti-Inflammatory, Anti-Wrinkle, Antimicrobial, Exfoliating, Fine Lines Reduction, Reduces Hyperpigmentation, Skin Lightening, Solubilizing

Technical Data SheetSafety Data Sheet

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Country of Origin
China
INCI Name
Capryloyl Salicylic Acid
Ingredient Origin
Synthetic
Cosmetic Ingredients Functions
Anti-Inflammatory,
Anti-Microbial Agent,
Anti-Wrinkle Agent,
Comedolytic Agent,
Exfoliant (Chemical),
Lightening Agent
Technologies
Cosmetic Ingredients
Product Families
Cosmetic Ingredients — Cosmetic Actives
Skin Actives

Features & Benefits

Benefit Claims
Anti-Inflammatory,
Anti-Wrinkle,
Antimicrobial,
Exfoliating,
Fine Lines Reduction,
Reduces Hyperpigmentation,
Skin Lightening,
Solubilizing
Labeling Claims
1,4-Dioxane-free,
Allergen-free,
Animal Products-free,
BSE-free,
Bisphenol A-free,
Butylated Hydroxyanisole-free,
CMR Substances-free,
Clean at Sephora,
Formaldehyde-free,
Fragrance-free,
Gluten-free,
Glycol ether-free,
Hormones-free,
Latex-free,
Nanomaterials-free,
Nitrosamines-free,
Non-GMO,
Non-Phenolic,
Not Listed In California Proposition 65,
Not Tested on Animals,
Odor-free,
Palm Oil-free,
Palm free,
Paraben-free,
Petrochemical-free,
Phthalates-free,
Silicone-free,
Soy-free,
Sulfate-free,
TSE-free,
Talc-free,
Ulta Beauty's Conscious Beauty

Applications & Uses

Markets
Personal Care
Applications
Personal Care — Beauty & Care
Bath & Shower,
Hair Care,
Skin Care,
Treatment Products
Application Format
Creams,
Leave On,
Rinse Off
Hair Care Applications
Hair Conditioner,
Shampoos & Rinses
Skin Care Applications
Anti-Spot Products,
Facial Scrub,
Moisturizers,
Skin Cleanser,
Skin Peels,
Skin Toners
Treatment Product Applications
Acne Treatments,
Rosacea (Redness) Treatment
Use Level
1.0 - 10.0%, 5-10% (for peels)

Properties

Physical Form
Powder
Appearance
White to off-white powder
Soluble in
Alcohol, Butylene glycol, Oil, Hexylene glycol, Pentylene glycol
Sparingly soluble in
Propanediol
Slightly Soluble in
Water
Typical Properties
ValueUnitsTest Method / Conditions
Assaymin. 98.0%-
Melting Point112.0-117.0°C-
pH4.5 - 6.0--
Chemical Composition
ValueUnitsTest Method / Conditions
Capryloyl Salicylic Acid Content100.0%-
Heavy Metals
ValueUnitsTest Method / Conditions
Arsenic Contentmax. 2ppm-
Lead Contentmax. 5ppm-
Mercury Contentmax. 1ppm-

Regulatory & Compliance

Chemical Inventories
AICS (Australia),
ENCS (Japan)

Technical Details & Test Data

Efficacy Testing Information

Method

Fifty female volunteers between the ages of 35 and 60 were treated with increasing peel concentrations (5-10% LHA or 20- 50% glycolic acid, GA).

Dermatologic evaluation of the face was performed before the peeling procedure and biweekly for 12 weeks.

In-vivo Testing of Effect on Lines and Wrinkles

MacDerma™ CSA - Efficacy Testing

From nine weeks on, Capryloyl Salicylic Acid significantly improved lines and wrinkles compared to baseline evaluations.

 

In-vivo Testing of Effect on Hyperpigmentation

MacDerma™ CSA - Efficacy Testing - 1

From seven weeks on, Capryloyl Salicylic Acid significantly improved hyperpigmentation compared to baseline evaluations.

Overall, a 5-10% Capryloyl Salicylic Acid peel is as effective as a 20-50% Glycolic Acid peel for reducing fine lines and wrinkles and facial hyperpigmentation.

Storage & Handling

Shelf Life
3 years
Storage Conditions

Seal and store away from light