Search
the marketplace
through 230,000 Chemicals and Raw Ingredients
through 8,000+ Supplier owned storefronts

MacDerma™ AZA

MacDerma™ AZA (Azelaic Acid) is a saturated dicarboxylic acid that exists as a white powder. Azelaic Acid is commonly derived from natural ingredients such as wheat, rye, and barley. It can also come from the Malassezia furfur (also known as Pityrosporum ovale), which is a yeast that lives on normal skin. It is the bacterial degradation of nonanoic acid that yields azelaic acid. MacDerma™ AZA has been known to reduce the appearance of skin discoloration and redness, acne, and other skin blemishes.

Brand: MacDerma (5 products)

INCI Name: Azelaic Acid

Functions: Anti-Inflammatory, Antioxidant, Lightening Agent, Whitening Agent

Ingredient Origin: Synthetic

Labeling Claims: 1,4-Dioxane-free, Allergen-free, Animal Products-free, BSE-free, Bisphenol A-free, Butylated Hydroxyanisole-free, CMR Substances-free, Clean at Sephora, Credo Clean Standard, Formaldehyde-free, Fragrance-free, Gluten-free, Glycol ether-free, Hormones-free, Latex-free, Nanomaterials-free, Nitrosamines-free, Non-GMO, Non-Phenolic, Not Listed In California Proposition 65, Not Tested on Animals, Palm Oil-free, Palm free, Paraben-free, Petrochemical-free, Phthalates-free, Silicone-free, Soy-free, Sulfate-free, TSE-free, Talc-free, Ulta Beauty's Conscious Beauty

Benefit Claims: Anti-Acne, Anti-Bacterial, Anti-Inflammatory, Antioxidant Properties, Blemish Control, Redness Reduction, Skin Lightening, Solubilizing, Whitening

Technical Data SheetSafety Data Sheet

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Country of Origin
China
INCI Name
Azelaic Acid
Ingredient Origin
Synthetic
Cosmetic Ingredients Functions
Anti-Inflammatory,
Antioxidant,
Lightening Agent,
Whitening Agent
Technologies
Cosmetic Ingredients
Product Families
Cosmetic Ingredients — Cosmetic Actives
Skin Actives

Features & Benefits

Benefit Claims
Anti-Acne,
Anti-Bacterial,
Anti-Inflammatory,
Antioxidant Properties,
Blemish Control,
Redness Reduction,
Skin Lightening,
Solubilizing,
Whitening
Labeling Claims
1,4-Dioxane-free,
Allergen-free,
Animal Products-free,
BSE-free,
Bisphenol A-free,
Butylated Hydroxyanisole-free,
CMR Substances-free,
Clean at Sephora,
Credo Clean Standard,
Formaldehyde-free,
Fragrance-free,
Gluten-free,
Glycol ether-free,
Hormones-free,
Latex-free,
Nanomaterials-free,
Nitrosamines-free,
Non-GMO,
Non-Phenolic,
Not Listed In California Proposition 65,
Not Tested on Animals,
Palm Oil-free,
Palm free,
Paraben-free,
Petrochemical-free,
Phthalates-free,
Silicone-free,
Soy-free,
Sulfate-free,
TSE-free,
Talc-free,
Ulta Beauty's Conscious Beauty

Applications & Uses

Markets
Personal Care
Applications
Personal Care — Beauty & Care
Bath & Shower,
Color Cosmetics,
Hair Care,
Skin Care,
Treatment Products
Application Format
Creams,
Leave On,
Lotions,
Rinse Off
Color Cosmetic Applications
Concealer,
Foundation
Hair Care Applications
Hair Conditioner,
Shampoos & Rinses
Skin Care Applications
Anti-Aging Products,
Astringent,
Body Firming Lotion,
Facial Cleanser,
Moisturizers,
Skin Toners
Treatment Product Applications
Acne Treatments,
Rosacea (Redness) Treatment
Use Level
0.1

Properties

Physical Form
Powder
Appearance
White to slightly yellow crystalline powder
Soluble in
Alcohol, Organic solvent
Partially Soluble in
Hot water
Typical Properties
ValueUnitsTest Method / Conditions
Assaymin. 98.5%-
pH4.0 - 5.0--
Chemical Composition
ValueUnitsTest Method / Conditions
Azelaic Acid Content100.0%-
Impurities
ValueUnitsTest Method / Conditions
Heavy Metalsmax. 10ppm-
Chlorides Contentmax. 50ppm-

Regulatory & Compliance

Chemical Inventories
AICS (Australia),
DSL (Canada),
ECL (Korea),
EINECS (EU),
ENCS (Japan),
IECSC (China),
NZIoC (New Zealand),
PICCS (Phillipines),
TSCA (USA)

Technical Details & Test Data

Efficacy Testing Information

 

Efficacy End Point Azelaic Acid Foam 15% (N=483) VehicleOnly(N=478) Azelaic Acid Foam 15% (N=198)

VehicleOnly(N=203)
Mean Change in # of Inflammatory Lesions from Baseline -13.2 -10.3 -13.3 -9.5
IGA Success Rate % 32.1 23.4 43.4 32.5

                             IGA indicates Investigator's Global Assessment

Subjects with inflammatory papules and pustules (n=1362, ages 19-92) from 2 randomized, double-blind studies applied 15% Azelaic Acid foam or vehicle-only twice daily for 12 weeks

Result: Azelaic Acid Foam 15% demonstrated superior performance compared to vehicle only.

 

Effect of 20% Azelaic Acid Cream on Skin Lightening.

In-vivo testing of effect on melasma and other facial hyperpigmentation

  • Fifty-two darker-skinned patients clinically diagnosed with at least moderate melasma or other facial hyperpigmentation were treated with a 20% Azelaic Acid cream or vehicle-only for 24 weeks.
  • Pigmentary intensity was measured by a chromometer and by physician assessment.

Result: Overall, Azelaic Acid treatment resulted in a significant decrease in pigmentary intensity compared to vehicle-only (p=0.021)

Storage & Handling

Shelf Life
3 years
Storage Conditions

Store in a cool, dry and well ventilated place in a tightly closed container.