Inyline® peptide solution

• Targets the post- synaptic pathway
• Disrupts AChR clustering
• Attenuates expression wrinkles

Science

• Each type of wrinkles usually develops on specific skin regions, responding differently to cosmetic and dermatological treatments. Facial frequent movements involve contraction and since the skin is anchored on the muscles underneath, it suffers the consequences through the years. So the modulation of muscle contraction is the most reliable approach to fight expression wrinkles. Muscle contraction is a complex mechanism formed by a number of different pathways, classified into two stages, presynapsis and post-synapsis.
• Inyline® peptide tackles the post-synaptic strategy inactivating the formation of the agrin/MuSK complex, thus preventhing acetylcholine receptor (AChR) clustering. By avoiding agrin binding to its receptor MuSK, two events are expected: neither MuSK is activated nor B-AChR subunit is phosphorylated, which are both required for a functional AChR clustering.

Inyline® peptide can be incorporated into cosmetic formulations such as emulsions, gels, serums to attenuate expression wrinkles.

Inyline® peptide is a novel approach into the cosmetic treatment of expression wrinkles, blocking the agrin binding site in MuSK and its mechanism of action causes modulation of muscle contraction leading to muscle relaxation.