Diffuporine® peptide solution

• Increases AQP₃ Levels 
• Improves skin moisturisation
• Maintains skin's youthful apperance

Science

• Skin not only protects us against the environment but regulates water exchange. Water is essential for the normal functioning of the skin, especially for the stratum corneum (SC) and skin barrier properties. Mechanisms that control water transport are not fully understood, but there is a continuous exchange of water between the SC, the living cells in the underlying epidermis and the atmosphere. Aquaporins are integral membrane  proteins involved in water transport through the different tissue layers, acting as water selective pores. AQP3 is the most abundant aquaglyceroporin in the human epidermis, facilitating the transport of water, glycerol and other small solutes. Therefore, AQP₃ improves transepidermal permeability, increasing water content in the skin surface and helping the barrier function.
• Diffuporine® peptide enhances AQP₃ expression levels in keratinocytes, which are inherently reduced due to chronologic aging and photoaging. In addition, this peptide presents further properties that contribute to maintaining skin barrier integrity and a youthful appearance.

Diffuporine® peptide can be incorporated into moisturizing formulations where an additional anti-aging effect is desired.

Diffuporine® peptide rejuvenates the skin by increasing skin moisturization, protein synthesis and cell proliferation. Furthermore, activation of AQP₃ increases SC water content and improves skin barrier function.