Delisens™ peptide solution

• Down - regulates PAR - 2 activity
• Attenuates neurogenic inflammation 
• Helps barrier function recovery

Science

• Sensitive skin is a disturbing condition that can be induced by environmental factors (e.g. pollution, UV radiation, dryness), lifestyle factors (e.g. cosmetics, soaps), psychological factors or hormonal factors. Sensitive skin may worsen and give rise to acute or chronic inflammation disorders, where the threshold for pruritic stimuli causing itch sensation is lowered. PAR-2 activation (endogenously by trypsin-like serine proteases) amplifies the inflammation via the up-regulation of inflammatory mediators (such as interleukin (IL)-6 and IL-8) and induces transient receptor potential vanilloid-1 (TRPV1) sensitisation, leading to the release of inflammatory peptides calcitonin gene-related peptide (CGRP) and substance P (SP) also involved in neurogenic inflammation. Furthermore, activated PAR-2 delays barrier function recovery in damaged skin, due to, for example, scratching after contact with some chemicals, like allergens.
• Delisens™ peptide down-regulates PAR-2 activity and as aresult CGRP, IL-6 and IL-8 release from skin cells, mediating neurogenic inflammation and therefore decreasing nagging pain sensation, discomfort and itching present in sensitive skin. It also helps to restore damaged tissue integrity, helping to the re-epithelisation and repair of damaged skin.

Delisens™ peptide can be incorporated into daily care formulations and any specific treatments for sensitive skin where a soothing and repairing effect is needed.

Delisens™ peptide ameliorates the discomfort of nagging pain and itch occurring in sensitive skin, besides restoring the damaged barrier integrity. In very dry sensitive skin, it increases hydration as well as improves scaling, smoothness and softness.