Somitine®

SOMITINE® boosts energy metabolism by stimulating ATP levels, thus recharging the cell's energy reserves. Cellular, basal and mitochondria respiration, and metabolic activity in the cells are stimulated. SOMITINE® increases cell regeneration and revitalizes the skin to restore its full radiance.

• ATP is the cell's fuel source and is a key component of energy metabolism. When ATP levels drop, the cell's "batteries" weaken. Once of the causes of this is reduced respiratory chain activity; energy metabolism thus decreases, the cells receive less oxygen, skin structures become disorganized and the skin is damaged.

• SOMITINE® recharges the cell's batteries and accelerates the energy cycle and metabolism by boosting the respiratory chain and glucose metabolism. Cell regeneration is increased, the skin is revitalized, better oxygenated, regaining its youthful look, radiance and brightness.

SOMITINE® acts on energy metabolism by stimulating the expression of genes (EDNRA, CYGB and KYNU) that induce ATP production, the cell's energy source.

CELL RESPIRATION RATE

• SOMITINE® stimulates cell basal respiration: global oxygen consumption rate increased by + 27%

                              3T3-LI cell basal respiration rate

• SOMITINE® stimulates mitochondrial respiration: rate of mitochondrial oxygen consumption increased by + 22%

                          3T3-LI cell mitochondrial respiration rate

Note:* p<0.05

CELLULAR ENERGY METABOLISM

• 5% SOMITINE® significantly increases the synthesis of adenyl nucleotides: ATP +14%, ADP + 39%, AMP + 18%.

                           Adenyl nucleotide synthesis by 3T3-LI cells

• 5% SOMITINE® does not alter the energy load inside the cells, equilibrium is reached and hence the catabolic and anabolic processes are balanced.

                                  Energy load in 3T3-LI cells

Note:* p<0.05

• SOMITINE®, by maintaining a stable energy load, is able to balance anabolic and catabolic processes, thus delaying cell aging.

In the cells, 5% SOMITINE® induces better basal and mitochondrial respiration rates. Energy metabolism is accelerated. Energy production, storage and release in ATP form are enhanced. In parallel to this, there is no energy imbalance: the cell uses up the additional energy produced.

ENERGY AND PHYSIOLOGICAL METABOLISMS

• Evaluation of respiratory metabolism in reconstructed epidermis SOMITINE® at concentrations of 1 and 5% increases glucose metabolism in reconstructed epidermis by 15% and 18% respectively under physiological conditions.

Under conditions of hypoxia, 1% and 5% SOMITINE® increases glucose metabolism by 23% and 24% respectively. SOMITINE® stimulates cell metabolism by using glucose. The stimulation of glucose utilization by cells under hypoxic conditions shows that SOMITINE® provides protection against metabolic damage, particularly respiratory metabolism.

Note: * p<0.05

RADIANT COMPLEXION

• 3% SOMITINE® increases brightness (L*) by a factor of 2 vs placebo.

                                        Framscan (Chromameter)
                       Double-blind / 10 volunteers / Twice daily application

• 3% SOMITINE® reduces the shiny appearance of skin by 50% vs placebo.

                           Goniolux (reflected light measurement)
                   Double-blind / 10 volunteers / Twice daily application

Note: *p<0.05