Silidine®

This micro-algae is a mixture of oligosaccharides and trace elements which stimulate expression of the gene coding for the protein responsible for smooth muscle vessel contraction (endothelin-I), in the capillaries, thereby inducing a constriction and an improvement of micro-circulation. By improving vascular tone, it corrects skin dysfunctions such as rosacea, as well as heavy leg syndrome.

SILIDINE® stimulates the expression of the endothelin-1 gene (ET-1) and hence the synthesis of this protein by endothelial cells (and fibroblasts) in the capillaries. The binding of ET-I to the surface receptors (ETA and ETB2) of smooth muscle cells induces a signal that diffused from the outside to the inside of the cell membrane and activates several effectors, ultimately leading to vasoconstriction, thus improving vascular tone.

• ET-1: Endothelin-1
• ETA: Endothelin-1 receptor, sub-type A
• ETB2: Endothelin-1 receptor, sub-type B2
   G: Protein G
• PLC: Phospholipase C
• PIP: Phosphatidyl inositol

• DAG: 1,2-diacylglycerol
• IP3: Inositol 1,4,5 - trisphosphate
• CaM: Calmodulin
• MLCK: Myosin Light Chain Kinase
   LC: Light myosin Chains
• P-LC: Phosphorylated Light myosin Chains

SILIDINE® stimulates the expression of the gene coding for endothelin-1, and hence the synthesis of this protein responsible for vascular smooth muscle contraction.

Obtained from the red alga Porphyrium cruentum by the metabolic induction technique.

The Porphyrium cruentum culture is subjected to oxidative stress resulting from an increase in oxygen levels by photosynthesis in the culture medium. Faced with this oxidative stress, the alga adapts its own metabolism to the changing environmental conditions, reacts, synthesizes various molecules of interest such as oligosaccharides and converts the trace elements present in the medium.

EFFECT ON REDNESS
• SILIDINE® reduced facial redness by 19%.The reduction was visible in 86% of volunteers

3% SILIDINE® (liquid) / 28 days / Double blind / 14 volunteers Twice-daily application

Note: * p<0.05

SILIDINE® improves vascular tone and helps to reduce the effects of rosacea such as redness.

EFFECT ON HEAVY LEG SYNDROME
• Variation in micro-circulation in 36% of volunteers*

Note: * 1% SILIDINE® (powder) / 28 days / 22 volunteers Twice-daily application

SILIDINE® improves vascular tone and helps to reduce heavy legs syndrome.

• SELF-EVALUATION TEST*

More than 70% of volunteers observed an improvement in:
> tired legs sensation
> heavy legs syndrome

Overall evaluation immediately after applying 1% SILIDINE®

Efficacy on skin properties

Efficacy on heavy leg sensations

Note:* 1% SILIDINE® (powder) / 28 days / 22 volunteers Twice-daily application