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Hebelys®

HEBELYS® is an advanced biotechnological active ingredient, designed using a systemic approach, to specifically address skin and emotional needs of the silver generation women and to support women after the age of 50 toward a positive aging, acting like a guardian of their golden age. HEBELYS® provides a sublimating effect on the physical impacts of skin aging and an uplifting effect on mood state.

Brand: Hebelys (1 products)

INCI Name: Sphingomonas Ferment Extract

Functions: Anti-Aging Agent

Ingredient Origin: Natural Origin

Labeling Claims: Allergen-free, BSE-free, CMR Substances-free, EDTA-free, GMO-free, Gluten-free, Glycol ether-free, Impurities-free, Nanomaterials-free, Natural, Nitrosamines-free, Non-Irritant, Non-Mutagenic, Non-Phototoxic, Non-Toxic, Not Tested on Animals, Phthalates-free, Preservative-free, Solvent-free, Sustainable, TSE-free, VOC-free, Vegan

Benefit Claims: Anti-Aging, Anti-Wrinkle, Cognition, Compatibility, Even Skin Tone, Long Lasting Freshness, Rejuvenating, Shine & Radiance, Skin Adhesion, Skin Tightening, Smoothing, Smooths Wrinkles, Suppleness

Certifications & Compliance: CFDA Compliant (China), EU Cosmetic Regulation 1223/2009 Compliant, FDA Compliant, GMP, IECIC (China), ISO 16128, ISO 22716

Technical Data SheetSafety Data Sheet

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

Carrier
Propanediol
INCI Name
Sphingomonas Ferment Extract
Ingredient Origin
Natural Origin
Cosmetic Ingredients Functions
Anti-Aging Agent
EINECS No.
231-791-2, 207-997-3
Technologies
Cosmetic Ingredients
Product Families
Cosmetic Ingredients — Cosmetic Actives
Skin Actives
Origin
  • Propanediol - Vegetable
  • Aqua - Mineral
  • Sphingomonas Ferment Extract - Bacterial

Features & Benefits

Benefit Claims
Anti-Aging,
Anti-Wrinkle,
Cognition,
Compatibility,
Even Skin Tone,
Long Lasting Freshness,
Rejuvenating,
Shine & Radiance,
Skin Adhesion,
Skin Tightening,
Smoothing,
Smooths Wrinkles,
Suppleness
Labeling Claims
Allergen-free,
BSE-free,
CMR Substances-free,
EDTA-free,
GMO-free,
Gluten-free,
Glycol ether-free,
Impurities-free,
Nanomaterials-free,
Natural,
Nitrosamines-free,
Non-Irritant,
Non-Mutagenic,
Non-Phototoxic,
Non-Toxic,
Not Tested on Animals,
Phthalates-free,
Preservative-free,
Solvent-free,
Sustainable,
TSE-free,
VOC-free,
Vegan
Product Background

SKIN & EMOTIONAL NEEDS OF SILVER GENERATION

According to demographic studies, 2020 will be a turning point: silver generation will outnumber children under age 5 (He et al., 2016). The rise of the silver generation reflects human effort to increase longevity and health. In the same time, mature women’s expectations have changed: they assume their age and its visible signs as well as they are more and more aware of the importance of an emotional wellbeing. From these trends a new dermo-cosmetic concept emerged: positive aging, which focuses on wellness to maintien health.

Many women attach self esteem to their body image which is associated with beauty, femininity and youth. Besides well-known deleterious effect of aging on physiological processes (formation of senescent « zombie cells » and spread of senescence, matrisome alteration) (Scudellari, 2017; FreitasRodriguez et al., 2017), aging has a negative effect on mood and self-esteem (Pearlman, 1993).

As a pioneer in the field of positive aging, GREENTECH developed HEBELYS®, an advanced biotechnological active ingredient, designed using a psychobiological approach. HEBELYS® specifically addresses skin and emotional needs of the silver generation women and supports women after the age of 50, acting like a guardian of their golden age.

 

Actions

  • Mechanisms Prevents & Reduces Senescent « Zombie Cells » Rejuvenates Dermal Matrisome & Dermis Integrity
  • Sublimates Wrinkles Texture Suppleness
  • Awakes Skin Radiance Freshness & Evenness
  • Uplifts Self-Esteem & Mood

 

Molecules

  • Polar Lipids

 

Sourcing

  • Sphingomonas hydrophobicum golden extremophilic microorganism

Applications & Uses

Skin Care Applications
Anti-Aging Products
Cosmetic Use
  • Positive Aging Skin Care
  • Premium Daily Skin Care
  • Mature / Silver Generation Skin Care
  • Preventive Care For Women Aged 50+
  • Holistic Anti-Wrinkle Skin Care
Formulations
  • Concentration for use: 1%
  • pH for use: 4.0 - 8.0
  • Caution for use: Add to emulsions, at the end of the preparation process under 40 °C.
  • Formulation guidelines and stability studies available on demand

Properties

Physical Form
Liquid
Odor
Characteristic
Appearance
Liquid
Soluble in
Water, Propanediol, 10% in water
Typical Properties
ValueUnitsTest Method / Conditions
Natural Content1%-
Natural Origin concentration100%-
Physico-Chemical Properties
ValueUnitsTest Method / Conditions
Dry Matter1.0 - 2.0%GT006
Refraction Index1.425 - 1.445-GT007
Quantifications
ValueUnitsTest Method / Conditions
Polar lipids (HPTLC)Presence-GT375
Specific Gravity1.030 - 1.080-GT008
Water Contentmax. 10.0%GT022
Microbiological Values
ValueUnitsTest Method / Conditions
Detection of EnterobacteriaAbsence-ISO 18415
Enumeration of Mesophilic Aerobic Bacteriamax. 100ufc/mL - cfu/mLISO 21149
Enumeration of Yeasts and Moldsmax. 100ufc/mL - cfu/mLISO 16212

Regulatory & Compliance

Certifications & Compliance
CFDA Compliant (China),
EU Cosmetic Regulation 1223/2009 Compliant,
FDA Compliant,
GMP,
IECIC (China),
ISO 16128,
ISO 22716
REACH Status
INCI Concentration REACH Status
Propanediol 88.0 - 99.0 % Propanediol registered
n°01-2119489383-28
Aqua <= 10,0 % Water exempted annex IV
Sphingomonas Ferment Extract 1.0 - 2.0 % Exempt: < 1 ton/year (dry matter)

 

Technical Details & Test Data

Aging Impacts

Initiation:

  • Aging/Exposome-induced signaling pathways: p21 or p16

Hebelys® - Aging Impacts

 

Hebelys® - Aging Impacts - 1

SENESCENT STATE = ZOMBIE CELLS:

  • Damaged aged cells that stay alive...
    But don’t work anymore!
  • Aged skin in vivo : 20-60% of «zombie fibroblasts».

SPREAD TO OTHER CELLS

  • Zombie cells» produce SASP* including inflammatory factors poisoning nearby cells and thus accelerating skin aging.

DERMAL MATRISOME

Proteins related to the dermal extracellular matrix (ECM).

  • Structural proteins
  • Adhesion proteins
  • Proteoglycans
    AGING: Glycation,aggregation, cross-linking 
  • A «young» matrix has a rejuvenating effect on zombie cells.

TO AGE WELL, KILL ZOMBIE CELLS !

 

Hebelys® - Aging Impacts - 2

Proven Efficacy - In Tubo/Vitro Test

Hebelys® - Proven Efficacy - in Tubo/Vitro Test

 

HEBELYS® PROMOTES A HEALTHIER & REJUVENATING CELLULAR ENVIRONMENT

REJUVENATES DERMAL MATRISOME

On aged 3D full-thickness skin model, with HEBELYS® (0.1%) or retinoic acid (100nM) during 42 days. Results normalized by the total dermal area. *p<0.05 vs control ; ***p<0.001 vs control

STRUCTURAL PROTEIN

Neocollagen I synthesis (+6%)

Collagen I is the most abundant structural protein of dermal extracellular matrix and is related to skin resistance.

Hebelys® - Proven Efficacy - in Tubo/Vitro Test - 1

 

ADHESION PROTEINS

Fibrillin expression (+22%***)

Fibrillin allows the adhesion of ECM components and plays a key role in the production of cytokines and growth factors.

Hebelys® - Proven Efficacy - in Tubo/Vitro Test - 2

 

PROTEOGLYCANS

Versican expression (+7%*)

Versican is linked to elastic fibers and promotes ECM organization. It has a key role is skin visco- elasticity.

Hebelys® - Proven Efficacy - in Tubo/Vitro Test - 3

Clinical Study - In Vivo

DESIGN

Double blind, open, intra-individual study. 24 silver generation women (60-70 yo).
Gel with HEBELYS® 1% vs placebo. Twice applications per day during 56 days. Evaluations at D0 and D56.
Instrumental evaluations: Fringe projection: wrinkles, isotropy ; Cutometer®: suppleness
Global visual effect on skin appearance standardized full face picture by VISIA®

Hebelys® - Clinical Study - in Vivo

 

Hebelys® - Clinical Study - in Vivo - 1

 

HEBELYS® offers a visible sublimating effect on mature skin

  • Emotions
  • Cognitive Process
  • Physiological Changes

Efficacy evaluation on 2 cognitive impacts of aging

2 SCIENTIFICALLY RECOGNIZED PSYCHOLOGICAL TESTS

SELF-ESTEEM
ROSENBERG TEST (ROSENBERG 1965)		 +10.5%***
MOOD STATE
PROFILE OF MOOD STATE (POMS) (MC NAIR 1971)		 +9%**

**p<0.01; ***p<0.001 D56 vs D0

Safety & Health

Toxicological Tests
Tests Method Tested Concentration Results
Skin Irritation Patch Test 2 % Very good skin compatibi
Mutagenicity Test Ames test Product tested at 7 dilutions Not mutagenic
Sensitization HRIPT 2 % Very good skin compatibility,Not
sensitizing
Eye Irritation Het cam 2 % Pratically non irritant
Phototoxicity 3T3 cells Product tested at 8 dilutions Not phototoxic

 

Storage & Handling

Shelf Life
24 months
Storage

15 / +25°C
Keep in the original packaging, without opening, in the recommended storage conditions.
Advice before use : Agitation