Dandrilys® NAT

• Natural & Safe Alternative To Zinc Pyrithione
• Microbiota-Powered Anti-Dandruff For A Healthier Scalp: Rebalances Bacteriobiota + Mycobiota
• Long-Lasting Action, Anti-Dandruff, Anti-Itching & Sebum Control

A SYSTEMIC APPROACH OF DANDRUFF (SCALP PHYSIOLOGY + MICROBIOTA)

Dandruff (also known as Pityriasis capitis) is characterized by itchy and flaky scalp with mild inflammatory reaction. It is a mild form of seborrheic dermatitis (Schwartz et al., 2013).
As summarized in the figure below, there are several extrinsic factors (like lack of hygiene, excessive use of hair sprays/gels/wax…) and intrinsic factors (like scalp microbiota dysbiosis, individual susceptibility, hormonal imbalances…) that seem to play a role in dandruff formation.
More precisely, this inflammatory chronic disorder is related to scalp skin barrier disruption, epidermal cellular proliferation and differentiation, as well as shifts in gene expression patterns, and in cytokine and lipid production (Bonnist et al., 2014).

Predisposing factors & interactions in the pathogenesis of dandruff. (adapted from Borda et al., 2015)

• Immunity
• Epidermal Barrier
• Genetics
• Neurogenic Factor
• Emotional Stress
• Nutrition
• Other

The scalp has a biotic network out of which Staphylococcus spp., Propionibacterium spp. and Malassezia spp are known components (the two first being part of bacteria and thus bacteriobiota, the later being part of yeast and thus mycobiota).
Dandruff has been closely associated to a scalp microbiota dysbiosis, with a disbalance in the proportion of these major fungal and bacterial population colonizing the scalp (Park et al., 2012). More precisely, the central dandruff hypothesis remains that the lipophilic yeast Malassezia, previously known as Pityrosporum, is the main causative agent of dandruff. Indeed, on the dandruff-afflicted scalp, the level of Malassezia increases to almost double the normal level. It has been found that some metabolic products of tryptophan produced by Malassezia, for example, indole derivatives, are the main cause of dandruff.
Aware of these mechanisms causing dandruff, GREENTECH R&D has developed a natural solution based on specific saponins (jujubosides) from Joazeiro bark to efficiently and quickly treat dandruff and rebalance scalp microbiota for a long-lasting effect. 

Clinical Study Design

• 22 male subjects (40-65 yo) with all hair & scalp types (dry-greasy-normal):
• 12 with adherent dandruff score ≥2.5 and total dandruff score ≥4.
  Shampoo: DANDRILYS 1% vs Placebo
• 10 with healthy scalp (control group).
  No treatment

Evaluation Parameters

• Scalp microbiota (high throughput DNA sequencing; bacteria: 16S ribosomal RNA; fungi: ITS1 ribosomal DNA)
• Total dandruff + Erythema/Irritation (for both grading; 0-5)

• DANDRILYS® REBALANCES SCALP BACTERIOBIOTA & MYCOBIOTA

 DANDRILYS® rebalances the BACTERIOBIOTA & MYCOBIOTA of scalp with dandruff towards a healthy scalp microbiota

• DANDRILYS® DECREASES BOTH DANDRUFF & ITCHING

 *p<0.05; **p<0.01; ****p<0.0001 vs D0 . Significant differences also vs placebo

Illustrative pictures after 5 washes (12 days) Double blind test on 23 subjects with middle to high level of dandruff (after washout). Shampoo with DANDRILYS® 1% vs placebo.

For Clinical Study 2 - In Vivo Test

Please refer this link:

https://media.knowde.com/image/upload/v1626161234/production/Collateral/259220/FicheDANDRILYS3voletscatalogue2021.pdf