Cola® Lipid GS

Background

Grapeseed oil is pressed from grapes and is a by-product of winemaking. It is especially high in ω-6 fatty acid, typically containing approximately 70% linoleic acid. It also contains up to 1.5% of unsaponifi able matter, including tocopherols and steroids. These compounds are of interest because they have the potential to provide added skin health benefi ts when the oil is converted to a surfactant. Grape seed extracts have been shown to have a variety of benefi ts, especially protection from oxidative stress. The Cola® Lipid line of multi-functional surfactants includes the grapeseed oil derivative Cola® Lipid GS, which was tested for its ability to function as an antioxidant via the ORAC test.

Method

Cola® Lipid GS was tested against an ORAC 6.0 panel which measures effi cacy against diff erent reactive oxygen species (ROS). Results are reported in μmol TE/g, where TE=Trolox equivalency, where Trolox is used as the test reference standard. Those in the panel that that demonstrated antioxidant activity were:

These results indicate a very high effi cacy against hydroxyl radicals and a smaller, but signifi cant, effi cacy against peroxynitrite, demonstrating that Cola® Lipid GS has a high likelihood of being eff ective as an antioxidant in a variety of skin care applications

Eye Irritation

MatTek Epi-Ocular: In vitro epidermal keratinocytes: Results indicate ‘non-irritating’ classifi cation.

Acute Skin Irritation

48 Hour Occlusive skin patch test: On human volunteers - 53 Test Subjects: no visible skin reaction, no potential for dermal irritation.

Skin Sensitization

Repeat Insult Patch testing (HRIPT): no potential for dermal irritation or allergic contact sensitization.

Biodegradability

OECD 301 (301D) Ready biodegradability test in an aerobic aqueous medium: Sample exceeds 75% biodegradability requirement in 14 day.

Cola® Lipid GS is shipped in 55 gallon poly drums (net weight 450 lb/204.1 kg).