Knowde Enhanced TDS
Identification & Functionality
- Chemical Family
- Ingredient Name
- Animal Feed & Nutrition Functions
- Ingredients
- L-Isoleucine
- Technologies
- Chemical Structure
Features & Benefits
- Animal Feed & Nutrition Features
- Benefits
Next limiting amino acid
- Isoleucine, together with Valine, is generally considered as the next limiting amino acids in monogastric animal diets.
Optimizing growth performance
- BCAAs are key amino acids for protein synthesis. Isoleucine optimizes the growth performance of animals by balancing BCAA in the feed.
Saving feed cost
- Isoleucine helps save feed costs by enabling reducing the use of expensive protein sources such as SBM.
Reducing N-excretion
- Low protein feeds reduce nitrogen excretion by increasing feed nitrogen utilization.
- Functions Of Isoleucine
Feed Intake And Protein Synthesis
- The supply of sufficient isoleucine is of great importance, as insufficient supply of BCAA activates GCN2 expression which results in reduced-feed intake and protein synthesis. Also, BCAA increases protein synthesis by activating mRNA expression Level.
Gut Health / Immunity
- BCAA increases expression of amino acid transporter in intestines, influencing intestinal functions. Isoleucine enhances immunity by increasing the expression of B-defensin, and production of e-NOS ſendothelial nitric oxide synthase), thereby immune system.
Nursery Performance
- Isoleucine enhances growth of mammary cells and fetal development through mTOR signaling pathway and expression of IGF-1 and 2 in fetal liver. Sows consume BCAA to synthesize Glutamate, Aspartate and Glutamine and increase milk protein content.
Improving Energy Efficiency
- Isoleucine increases glucose uptake and energy efficiency in intestine and muscle by the expression of intestinal and muscular glucose transporters.
Applications & Uses
- Markets
- Recommendation Of Isoleucine Ratio To Lysine %
Properties
Technical Details & Test Data
- Metabolism Of Isoleucine
Mechanism mainly occurs in skeletal muscles and plays a very important role in muscle protein formation.
Balance of BCAA contents is important, since BCAAS share enzymes (BCAT and BCKDH) with each other. When the balance is broken, the growth performance and immune system deteriorate.
For some feedstuffs (especially blood products), the leucine content can be very high, the addition of isoleucine should be considered.
Packaging & Availability
- Packaging Type