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ErgoActive® L-Ergothioneine

ErgoActive® L-Ergothioneine is a potent antioxidant that works inside cells to combat oxidative stress. While ergothioneine is synthesized mainly in mushrooms, fungus and soil bacteria, human cells express a transporter highly specific to ergothioneine. Despite not being produced in the body, ergothioneine is present in nearly all human cells, suggesting its significance in supporting human health. An in vitro study demonstrates that ErgoActive ® preserved telomere length and reduced the rate of telomere shortening under oxidative stress conditions, supporting the benefit of ergothioneine for healthy aging. Emerging science shows potential cognitive, immune, prostate and cardiovascular health benefits.

Brand: ErgoActive (1 products)

INCI Name: Ergothioneine

Ingredient Name: L-Ergothioneine

Ingredient Origin: Fermentation

Functions: Antioxidant

Labeling Claims: Clean at Sephora, Credo Clean Standard, GMO-free, Gluten-free, Kosher, Non-GMO, Odor-free, Sustainable, Ulta Beauty's Conscious Beauty, Vegan

Synonyms: (2S)-3-(2-Sulfanyl-1 H -imidazol-4-yl)-2-(trimethylazaniumyl)propanoate, (S)-5-(2-Carboxy-2-(trimethylammonio)ethyl)-1 H -imidazole-2-thiolate, 2-Mercapto- N,N -dimethylhistidine Methyl Ester Betaine, 2-Mercaptohistidine Betaine, 2-Mercaptohistidine Trimethylbetaine, Histidine, 2-mercapto- N,N -dimethyl-, Betaine, Histidine, 2-mercapto-, Trimethylbetaine, NSC 7175

Enhanced TDS

Knowde-enriched technical product data sheet

Identification & Functionality

INCI Name
Ergothioneine
Ingredient Name
L-Ergothioneine
Ingredient Origin
Fermentation
Cosmetic Ingredients Functions
Antioxidant
Food Ingredients Functions
Antioxidant
Pharma & Nutraceuticals Functions
Antioxidant
CAS No.
497-30-3
EC No.
207-843-5
Technologies
Cosmetic Ingredients,
Food Ingredients,
Pharmaceuticals & Nutraceuticals
Product Families
Cosmetic Ingredients — Cosmetic Actives
Skin Actives
Pharmaceuticals & Nutraceuticals — Nutraceuticals & Supplements
Antioxidants,
Proteins & Amino Acids,
Supplements & Functional Ingredients,
Vitamins
Food Ingredients — Nutrition & Fortification
Antioxidants,
Functional Ingredients,
Proteins & Amino Acids,
Vitamins
Cosmetic Ingredients — Vitamins, Extracts & Oils
Vitamins & Derivatives

Features & Benefits

Benefit Claims
Antioxidant Properties,
Cardioprotective,
Enhances Mitochondrial Health,
Healthy Ageing,
Hepatoprotection,
Improves Cognitive Health,
Improves Sleep Quality,
Oxidation Protection,
Preservation,
Stimulates Immune System,
UV Protection
Benefit Claims (Health)
Antioxidant Properties,
Cardioprotective,
Enhances Mitochondrial Health,
Hepatoprotection,
Improves Cognitive Health,
Improves Sleep Quality,
Stimulates Immune System
Labeling Claims
Clean at Sephora,
Credo Clean Standard,
GMO-free,
Gluten-free,
Kosher,
Non-GMO,
Odor-free,
Sustainable,
Ulta Beauty's Conscious Beauty,
Vegan
Food Ingredients Features
Healthy Ageing,
Neutral Taste
Product Highlights

Known as a “longevity vitamin” by Dr. Bruce Ames, L-ergothioneine (L-ET) is an amino acid with potent antioxidant properties that is found in foods such as mushrooms, beans, and chicken and pork liver. Human cells express a highly specific transport protein called the ergothioneine transporter (ETT), leading many researchers to investigate its importance to several areas of human health. ErgoActive®  is a sustainable source of highly pure L-ergothioneine without reliance on intensive farming or inconsistent harvests.

Advantages of ErgoActive®
  • Demonstrated in a first-of-kind in vitro study to support telomeres
  • US FDA no objection to notification of self-armed GRAS (GRN No. 734)
  • Sustainably produced using a proprietary fermentation process
  • GMO-free, vegan, and kosher certified
  • Water-soluble powder, and neutral in taste, color and odor

Applications & Uses

Markets
Food & Nutrition,
Personal Care
Applications
Personal Care — Beauty & Care
Skin Care
Food & Nutrition — Nutrition & Well Being
Nutraceuticals & Supplements
Benefit Areas
  • Mitochondrial Function
  • Antioxidant Support
    • L-Ergothioneine is concentrated in mitochondria and protects mitochondrial DNA from oxidative damage.
  • Cognitive Health
    • Age-associated declines in blood L-ET levels may be associated with a risk of mild cognitive impairment (MCI) in healthy elderly.
    • The consumption of mushrooms has also been inversely associated with MCI.
  • Telomere Support
  • Healthy Aging
    • Under oxidative conditions ErgoActive® reduced the telomere shortening rate by 27-52% at 4 weeks compared to cells that were not treated with L-ET.
  • Skin Health
    • Skin cells express the ETT, which allow them to take up, accumulate, and use L-ET to protect against oxidative stress.
    • Ergothioneine inhibits UV-induced reactive oxygen species (ROS) production and subsequent skin cell damage.

Properties

Physical Form
Powder
Solubility
Water Soluble

Regulatory & Compliance

Certifications & Compliance
FDA Compliant,
Generally Recognized As Safe (GRAS),
Kosher

Technical Details & Test Data

Clinical Studies

Cognition Support
Increasing age has been associated with decreasing blood levels of ergothioneine and a greater incidence of mild cognitive impairment (MCI).

  • In a 2016 study, researchers found that blood ergothioneine levels in elderly declined significantly (P < 0.01, r = -0.2159) beyond 60 years of age.
  • This decrease in ergothioneine may indicate that low ergothioneine is a risk factor for neurodegeneration in the elderly.
  • The consumption of mushrooms has also been inversely associated with MCI.

 Ergothioneine and Telomeres

Shortened telomeres are associated with aging and age-related diseases, and oxidative stress is thought to be a major contributor to telomere shortening.

  • In a recent in vitro study, ergothioneine preserved telomere length and reduced the rate of telomere shortening under oxidative stress conditions, suggesting ergothioneine as beneficial for healthy aging.