Enhanced TDS
Knowde-enriched technical product data sheet
Identification & Functionality
- INCI Name
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
- Product Properties
- BioCell Collagen® has strong hyaluronidase inhibition
- BioCell Collagen® protects HA from degradation
- BioCell Collagen® provides collagen peptides and hyaluronic acid.
HA level in the skin is maintained by the balance of HA synthases and hyaluronidases. Aging is associated with heightened hyaluronidase activity which accelerates HA breakdown contributing to skin aging process.
- Dermatologist Reviewed
- Non-Irritating
- Allergy Tested
- Non-Cytotoxic
Applications & Uses
- Markets
- Applications
- Skin Care Applications
- Cosmetic Applications
- Anti-Aging Cosmetic Products
- Moisturizing Cosmetic Products
- Oil-Free Hydrating Cosmetic Products
- Usage
- Formulators and manufacturers of cosmetics.
- Applications
- BioCell Collagen® CG should be processed below 40 °C and is incorporated into the aqueous phase of a cosmetic formulation.
Properties
- Physical Form
- Soluble in
- Water
- Typical Properties
Value Units Test Method / Conditions pH Value (55°C) 3.7 - 4.5 - - - Microbiological Values
Value Units Test Method / Conditions Standard Plate Count max. 3000 CFU/g AOAC Petrifilm Yeast and Mold Count max. 500 CFU/g AOAC Petriflm Salmonella Negative USP E. coli Negative USP
Technical Details & Test Data
- Research Data
1. Toxicology and allergenicity studies Our early studies showed that BioCell Collagen CG-WS was hypoallergenic on the human skin and did not have cytotoxicity on the cells tested.
2. Hyaluronidase inhibition study
What is unique with BioCell Collagen is its inhibitory activity of hyaluronidase. HA is present in virtually all tissues and bodily fluids while one third of HA is turned over daily by coordinated action of HA synthases and hyaluronidases. Our study showed that hyaluronidase was specifically inhibited by BioCell Collagen in a dose-dependent fashion.
Given that hyaluronidase-mediated degradation of HA is implicated in various aging-associated physiological conditions, BioCell Collagen’s property of inhibiting hyaluronidase may have a profound implication especially in terms of aging processes which takes place in the joint and the skin. This data suggested that BioCell Collagen had multiple biological properties in addition to replenishment of structural loss of collagen and HA in aging skin that can be harnessed to maintain the integrity and amount of HA for younger-looking skin.
Packaging & Availability
Storage & Handling
- Storage
2 Years / Cool dry place