Knowde Enhanced TDS
Identification & Functionality
- Active Component
- Ingredient Name
- Ingredient Origin
- Pharma & Nutraceuticals Functions
- Product Families
- Plant Source
Root
Features & Benefits
- Benefit Claims (Health)
- Labeling Claims
- Food Ingredients Features
- Product Overview
- Plants from the Berberis genus have been widely used in traditional Asian medicine for their health benefits for centuries; among them, a particular species - Berberis aristata - is also mentioned in the Ayurvedic Pharmacopeia of India.
- From a scientific point of view, berberine is recognized as a natural derived bioactive alkaloid obtained from the berberis genus plants, proven to favorably modulate blood profiles such as plasma lipids and glucose levels, therefore contributing to metabolic wellbeing.
- Find a way to keep our metabolism balanced is one of our time’s main global health targets, in order to fight multifactorial noncommunicable disorders such as metabolic syndrome, PCOS or type-II diabetes.
- That’s where the journey started. This urgent need gave birth to Berbevis®, your natural ally for a healthy metabolism: an innovative berberine extract obtained from Berberis aristata with an optimized bioabsorption profile, thanks to its Phytosome® delivery system.
- BERBEVIS® Features and Benefits
BERBEVIS®, is a next-generation Phytosome® with a new custom formulation leveraging onto 3 additional pillars:
- Berberis aristata extract is more soluble than pure berberine in simulated gastrointestinal fluids.
- using pea proteins within the Phytosome® matrix helps optimize berberine bioabsorption, as reported in scientific literature.
- using Indena's grape seed extract as a powerful, natural antioxidant to protect the intestinal mucosa against the known gastrointestinal adverse effects of traditional berberine, thus optimizing its tolerability even in long term use.
Since PCOS is an endocrine-metabolic disorder very similar to metabolic syndrome, they share an altered sugar profile: that's why Indena decided to test BERBEVIS® in the management of healthy blood sugar levels, to greatly support metabolic wellbeing.
- It optimizes insulin resistance significantly, after as few as 30 days of treatment, achieving a remarkable -49% at the end of the study (based on HOMA index value)
- It noticeably optimizes the blood sugar profile positively modulating blood glucose and insulin
- according to the study’s multiple endpoints, BERBEVIS® emerged as the winning multi-target approach to PCOS thanks to an effective modulation over blood sugar levels.
Furthermore, BERBEVIS®:
- has a positive effect on body composition, inducing the redistribution of adipose tissue
- positively supports hormonal balance
- is also helpful against acne, tipical symptom of PCOS, both reducing discomforts and thus improving quality of life.
- Health Benefits
Blood glucose homeostasis, Hormonal control , Metabolism balance
Applications & Uses
- Markets
- Food & Nutrition Applications
- Use Level
- 550 mg/day (2x)
Properties
- Appearance
- Light brown powder
- Assay
| Value | Units | Test Method / Conditions | |
| Berberine | 28 – 34 | % | HPLC Method |
Technical Details & Test Data
- Scientific Evidence
BERBEVIS® is supported by a human pharmacokinetics and two human studies.
- Berbevis® into Action
- In recent years, berberine has received widespread attention due to its good potential for optimal metabolic wellbeing during our lifespan.
- Its efficacy is linked to the berberine’s so-called “Cloud Effect”: its pleiotropic action that simultaneously affects either root causes (e.g. low-grade chronic inflammation, oxidative stress, gut microbiota modulation) or visible effects (e.g. insulin response) through the modulation of several cellular targets (e.g. AMPK, mitochondria, insulin-receptors, key metabolic enzymes, etc.).
- To confirm its multi-target potential, Berbevis® has been extensively studied in in vitro, in vivo and human studies where it showed to effectively support metabolic health, favorably modulating insulin response; improving the blood sugar profile, leveling both blood glycemic and insulin; optimizing the blood lipid profile; having a positive effect on body composition and inducing the redistribution of adipose tissue.
- Furthermore, other studies highlighted its activity promoting hormonal balance and its positive effect on low-grade chronic inflammation.