Knowde Enhanced TDS
Identification & Functionality
- Carrier
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
- Origin
- DermalRx® HydroSeal, produced via a biofermentation process that uses a proprietary strain of yeast, helps to fortify the skin’s natural barrier structures and restores its normal moisture retention capacity.
Features & Benefits
- Benefit Claims
- Labeling Claims
- Benefits & Claims
- Biofermentation-derived active produced using a proprietary strain of yeast
- Supports the rebuilding of strong cell-to-cell junctions
- Stimulates synthesis of type I collagen in fibroblasts
- Repairs damaged skin barrier restoring its natural ability to retain moisture
- Promotes skin remodeling and structural integrity
- Well-documented anti-aging and moisturizing activity in vivo under extreme, cold wintery conditions
Applications & Uses
- Markets
- Color Cosmetic Applications
- Skin Care Applications
- Use Level
- 1 - 3%
- Applications
- Anti-aging systems targeting improvement in skin’s barrier function and wrinkle reduction
- Soothing and calming formulations for sensitive skin
- Products to treat damaged skin barrier after invasive topical procedures (laser, dermabrasion, etc.), and lip care formulations
- High performance moisturization products for dry, damaged skin
- Compatibility and Formulation
- DermalRx® HydroSeal is water miscible and is compatible with conventional ingredients used in skin care products. Add to product at temperatures below 50°C. DermalRx® HydroSeal has no effect on the color of final formulations when incorporated at recommended use levels.
Regulatory & Compliance
- Certifications & Compliance
- Regulatory Information
- This product has not been tested on animals, and our company adheres to the written provisions of such animal rights organizations as Leaping Bunny and Cruelty/Free International.
- This product contains no animal products. It is manufactured using only plant based or synthetically derived (non-animal origin) materials and is thereby declared a Vegan Product.
- All materials used to produce this product are procured using sustainable sourcing practices.
- This product is manufactured in accordance with the current Good Manufacturing Practices (cGMP) requirements established by the U.S. Food and Drug Administration (FDA) for cosmetics. Furthermore, Biocogent, LLC, and this production facility(ies), are registered as cosmetic manufactures with the FDA.
- REACH compliance: All of the ingredients (substances) used in the manufacture of this product (mixture)are either registered under REACH, or qualify for an Article 2 (low volume of less than 1 metric ton), Annex IV or Annex V exemption, making our product REACH compliant.
- Proposition 65 compliance: Based upon Biocogent LLC’s knowledge of our business operations and chemical formulations, no chemicals listed by the State of California Environmental Protection Agency are used in our products, or as a processing aid for any product manufactured in our facility.
Technical Details & Test Data
- Test Data
Reduction of Wrinkle Appearance
DermalRx® HydroSeal visibly reduced the appearance of wrinkles after twice-daily applications of 2% DermalRx® HydroSeal for 4 weeks.
Reduction of Transepidermal Water Loss (TEWL)
In a clinical study, a one-time application of 3% DermaIRx® HydroSeal decreased TEWL by almost 30%.
Safety & Health
- Safety
- Human Repeat Insult Patch Testing (HRIPT) under semi-occlusive conditions indicated that DermalRx® HydroSeal did not perform as a primary skin irritant or as a primary skin sensitizer at recommended use levels. Ocular irritation testing predicted that DermalRx® HydroSeal would be a Minimal ocular irritant at recommended use levels. No cytotoxic effects were reported on the viability of Human Epidermal Keratinocytes exposed to DermalRx® HydroSeal.
Storage & Handling
- Shelf Life
- 18 Months
- Storage Condition
- DermalRx® HydroSeal should be stored at room temperature in original packaging away from heat and light.