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Soluplus®

1 of 1 products in this brand
Soluplus® is a polymeric solubilizer with an amphiphilic chemical structure, which was particularly developed for solid solutions. Due to its bifunctional character, it is able to act as a matrix polymer for solid solutions on the one hand, and, on the other hand, it is capable of solubilizing poorly soluble drugs in aqueous media. Furthermore, Soluplus® can increase the bioavailability of poorly soluble drugs.

Chemical Name: Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer

CAS Number: 402932-23-4

Functions: Anti-Crystallizing Agent, Bioavailability Enhancer, Filler, Film Former, Matrix Forming Agent, Solubilizer, Stabilizer

Dosage Form: Dispersions, Transdermal Patches

Labeling Claims: Sustainable

Certifications & Compliance: China DMF, DMF Type IV, DMF Type V, US DMF, cGMP

Technical Data Sheet
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Knowde Enhanced TDS

Identification & Functionality

Chemical Name

Polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer

Country of Origin

Germany

Pharma & Nutraceuticals Functions

Anti-Crystallizing Agent,

Bioavailability Enhancer,

Filler,

Film Former,

Matrix Forming Agent,

Solubilizer,

Stabilizer

Technologies

Pharmaceuticals & Nutraceuticals

Product Families

Pharmaceuticals & Nutraceuticals — Excipients

Emulsifiers & Stabilizers,

Fillers & Diluents,

Formulation & Processing Aids,

Other Excipients,

Pharmaceutical Coatings,

Solvents & Solubilizers

Features & Benefits

Labeling Claims

Sustainable

Key Benefits
  • Outstanding solubilization properties, especially for poorly soluble APIs
  • Solubility effects due to pH shifts can be avoided
  • Enables bioavailability enhancement
  • Soluplus® with its glass transition temperature of around 70°C is a well extrudable polymer and shows no chemical degradation even after extrusion at 220°C.
  • Ideal for hot melt extrusion

Applications & Uses

Markets

Healthcare & Pharma

Applications

Healthcare & Pharma — Drug Delivery & Care Solutions

Oral,

Topical,

Transdermal

Dosage Form

Dispersions,

Transdermal Patches

Manufacturing Technology

Hot Melt Extrusion,

Melt Granulation,

Spray Drying

Properties

Physical Form

Capsules,

Granules,

Solid,

Tablets

Appearance
White to yellowish granules

Regulatory & Compliance

Certifications & Compliance

China DMF,

DMF Type IV,

DMF Type V,

US DMF,

cGMP

Chemical Inventories

TSCA Exempt (USA)

Packaging & Availability

Packaging Type

Boxes,

Drums,

Jerrycan

Packaging Information
  • 0.5KG Plastic bottle (Sample)
  • 12.5KG Plastic drums
  • 25KG Fibreboard boxes

Storage & Handling

Storage Information & Retest Period
  • Store below 30°C. Store in tight containers, protect from light, moisture and freezing. Carefully reseal the container after opening.
  • Retest Period : 36 months