Knowde Enhanced TDS
Identification & Functionality
- Carrier
- INCI Name
- Ingredient Origin
- Cosmetic Ingredients Functions
- Technologies
- Product Families
Features & Benefits
- Benefit Claims
- Labeling Claims
Applications & Uses
- Markets
- Color Cosmetic Applications
- Hair Care Applications
- Skin Care Applications
- Use Level
- 3.0 – 5.0%
- Mode of Action
Premature, accelerated loss of hair, also known as Alopecia, can be caused by various factors. Frequently, it is due to functional disorders in the hair growth cycle. Follicusan DP stimulates cellular functioning in the scalp and in the hair follicles and thus counteracts premature loss of hair, as could be demonstrated in a study. A gel containing 5 % Follicusan DP, used over a period of three months, was found to normalize hair growth cycles in individuals suffering from Alopecia diffusa and Alopecia androgenetica, which was proven by preparing trichograms: The number of anagen hair follicles (growth stage) was found to have increased and that of telogen hair follicles (resting stage) decreased.
Follicusan DP helps prevent functional disorders of the scalp by vitalizing the cells. Furthermore,due to its active ingredient composition, it can normalize excess sebum secretion, thus counteracting formation of dandruff.
- Recommended Uses
- Follicusan DP is designed for the preventative care of scalp and hair.
- It can be used in aqueous and aqueous-alcoholic hair care formulas.
- Processing
Follicusan DP is present in an aqueous buffer solution (citrate buffer pH=6.5) containing an ethanol share of 15 %. In preparations containing Follicusan DP the pH range 3.5 to 5.8 should be avoided, as precipitations may occur due to the isoelectric points of proteins.
Properties
- Physical Form
- Odor
- Characteristic
- Appearance
- Opaque particle-free liquid
Technical Details & Test Data
- Product Solubility
Follicusan DP used at the recommended maximum concentration of 5 % dissolves in water and in water-alcohol mixtures with a maximum alcohol content of 50 % v/v.
Safety & Health
- Physiological Safety
LD50 oral (the procedure used to produce Follicusan DP does not chemically alter the raw
materials used; therefore, the oral toxicity value indicated for Follicusan DP is deduced from the
toxicological values found for its raw materials):
> 2500 mg/kg animal weight (rat): non-toxicEye irritation Potential
Follicusan DP, undiluted, was tested on the chorioallantoic membrane of the hen's egg where it produced an irritation score of 0.39 and therefore was classified as "not irritant".
Skin compatibility
- Human Patch Test (primary irritation test)
An O/W cream containing 10% of Follicusan DP was applied on 50 volunteers (among these 26 individuals with normal skin, 2 sufferers from eczema, 4 allergic and 18 individuals with sensitive skin) for 48 hours in a patch test. This test showed neither skin irritant nor sensitizing effects. Thus Follicusan DP can be classified as harmless as regards the possibility of skin irritation in the advised dose.
- Human Repeated Insult Patch Test (HRIPT)
A gel containing 10 % Follicusan was tested on 50 volunteers (repeated application) for 4 weeks. Due to the results obtained the product could be designated as highly skin
compatible from a dermatological point of view; it did not produce any skin irritating
effects, nor signs of skin sensitization.
Note: Follicusan DP is identical to Follicusan, except for the fact the Follicusan DP does not contain Methylparaben, whereas Follicusan does.Mutagenicity
According to a reverse mutation assay using bacteria Follicusan DP showed neither on 4 strains of Salmonella typhimurium nor on E. coli WP2 uvrA any mutagenic action.
Phototoxicity
Follicusan DP was applied at different concentrations (0.3 – 1000 μg/ml) on BALB/3T3 cells for 1 hour and further 50 minutes in absence and presence of a non-toxic dose of UVA light. One day after treatment the cytotoxicity was analyzed (neutral red uptake) and compared to controls. In this study Follicusan DP showed no phototoxic effects.
Packaging & Availability
- Packaging Information
- Available pack sizes: 1 kg, 5 kg, 25 kg
- Sample size: 50 g
Storage & Handling
- Storage and Handling
If kept at a temperature of 15°C to 25°C, protected from light and in well-closed containers, Follicusan DP is stable for at least 2 years. Product packs should be fully used once opened.
- Preservative System
- Phenoxyethanol
- Sodium dehydroacetate